STUDY FOR REGULATION OF MOUSE ERYTHROPOIESIS BY SUPERNATANTS OF CULTURED PERITONEAL MACROPHAGE

Zhu Bide; et al

doi:10.13406/j.cnki.cyxb.1990.04.006

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STUDY FOR REGULATION OF MOUSE ERYTHROPOIESIS BY SUPERNATANTS OF CULTURED PERITONEAL MACROPHAGE

更新时间：2024-01-17

- STUDY FOR REGULATION OF MOUSE ERYTHROPOIESIS BY SUPERNATANTS OF CULTURED PERITONEAL MACROPHAGE
- Journal of Chongqing Medical University Issue 4, Pages: 272-277(1990)
- 作者机构：
  
  重庆医科大学组织胚胎学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1990.04.006
  CLC：
- Published：1990，
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[1]祝彼得,郭瑞清.腹腔巨噬细胞培养上清液对小鼠红系造血调控的研究[J].重庆医科大学学报,1990(04):272-277.

Zhu Bide, et al. STUDY FOR REGULATION OF MOUSE ERYTHROPOIESIS BY SUPERNATANTS OF CULTURED PERITONEAL MACROPHAGE. [J]. Journal of Chongqing Medical University (4):272-277(1990)
[1]祝彼得,郭瑞清.腹腔巨噬细胞培养上清液对小鼠红系造血调控的研究[J].重庆医科大学学报,1990(04):272-277. DOI： 10.13406/j.cnki.cyxb.1990.04.006.

Zhu Bide, et al. STUDY FOR REGULATION OF MOUSE ERYTHROPOIESIS BY SUPERNATANTS OF CULTURED PERITONEAL MACROPHAGE. [J]. Journal of Chongqing Medical University (4):272-277(1990) DOI： 10.13406/j.cnki.cyxb.1990.04.006.

摘要

本文研究了未刺激和经大肠杆菌内毒素（LPS）刺激的腹腔巨噬细胞培养上清液对小鼠红系造血的调控作用。结果提示:未刺激和经LPS刺激腹腔巨噬细胞培养上清液对早期红系祖细胞（BFU-E）均呈刺激作用

对晚期红系祖细胞（CFU-E）呈双向调控

即低浓度刺激

高浓度抑制。二者比较

LPS刺激腹腔巨噬细胞培养上清液具有更高调控活性。实验还提示

腹腔巨噬细胞培养上清液具有促红细胞生成素（EPO）、BPA（Burst Promoting Activity）样活性

Abstract

The effect of cultured supernatants of non-stimulated and LPS-induced peritoneal macrophages on erythropoiesis in C57BL/6J mice was studied by using the techniques of culture of hemopoietic progenitor cells in vitro. Our results indicate that(l)BFU-E growth is enhanced significantly after addition of either non-stimulated or LPS-induced supernatants of peritoneal macrophages; (2) the supernatants present positive and negative feedback control on CFU-E

growth-low concentration supernatants stimulate CFU-E and high concentration supernatants present inhibition; (3) the LPS-induced supernatants of peritoneal macrophage show stronger activities than non-stimulated supernatants to the proliteration of both BFU-E and CFU-E and(4)the supernatants of the cultured peritoneal macrophage may contain EPO-like

BPA-like stimulating activities

which regulate the proliferation of both BFU-E and CFU-E

关键词

巨噬细胞BFU-ECFU-E红系血发生促红细胞生成素BPA

Keywords

macrophageBFU-ECFU-EE rythropoiesiserythropoietinBPA

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