THE ALTERATION OF T-LYMPHCYTE NUMBER AND PERITONEAL MACROPHAGE PHAGOCYTOSIS IN STREPTOZOTOCIN-INDUCED DIABETIC MICE

Li Qifu et al

doi:10.13406/j.cnki.cyxb.1990.04.002

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THE ALTERATION OF T-LYMPHCYTE NUMBER AND PERITONEAL MACROPHAGE PHAGOCYTOSIS IN STREPTOZOTOCIN-INDUCED DIABETIC MICE

更新时间：2024-01-17

- THE ALTERATION OF T-LYMPHCYTE NUMBER AND PERITONEAL MACROPHAGE PHAGOCYTOSIS IN STREPTOZOTOCIN-INDUCED DIABETIC MICE
- Journal of Chongqing Medical University Issue 4, Pages: 262-265(1990)
- 作者机构：
  
  1. 重庆医科大学第一医院内科
  2. 重庆医科大学第一医院内科内分泌研究生
  3. 内分泌
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1990.04.002
  CLC：
- Published：1990，
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[1]李启富,舒昌达,何军.链脲霉素糖尿病小鼠外周血T淋巴细胞数量和腹腔巨噬细胞吞噬功能研究[J].重庆医科大学学报,1990(04):262-265.

Li Qifu et al. THE ALTERATION OF T-LYMPHCYTE NUMBER AND PERITONEAL MACROPHAGE PHAGOCYTOSIS IN STREPTOZOTOCIN-INDUCED DIABETIC MICE. [J]. Journal of Chongqing Medical University (4):262-265(1990)
[1]李启富,舒昌达,何军.链脲霉素糖尿病小鼠外周血T淋巴细胞数量和腹腔巨噬细胞吞噬功能研究[J].重庆医科大学学报,1990(04):262-265. DOI： 10.13406/j.cnki.cyxb.1990.04.002.

Li Qifu et al. THE ALTERATION OF T-LYMPHCYTE NUMBER AND PERITONEAL MACROPHAGE PHAGOCYTOSIS IN STREPTOZOTOCIN-INDUCED DIABETIC MICE. [J]. Journal of Chongqing Medical University (4):262-265(1990) DOI： 10.13406/j.cnki.cyxb.1990.04.002.

摘要

采用链脲霉素诱导C

小鼠发生糖尿病并研究在糖尿病状态下

外周血T淋巴细胞数量和腹腔巨噬细胞吞噬功能。结果显示糖尿病小鼠外周血淋巴细胞数量无明显改变

而T淋巴细胞百分比显著下降;腹腔巨噬细胞体外吞噬酵母菌的能力明显低于正常对照。T淋巴细胞数量减少和巨噬细胞吞噬功能减弱

提示链脲霉素糖尿病小鼠细胞免疫功能低下

Abstract

The peripheral T-lymphocyte number and phagocytic function of peritoneal macro-phages were studied in diabetic C57 mice induced by streptozotocin.. No significant difference in the peripheral lymphcyte number was found

but the percentage of T-lymphocytes quantitated by ANAE staining significantly decreased in diabetic mice. The phagocytic activity of yeasts by peritoneal macrophages was apparently lower in diabetic mice than in normal control. The decrease of T-lymphocytes and depressed phagocytosis of macrophages suggest impaired function of cell-mediated immunity in streptozotocin-induced diabetic mice

关键词

糖尿病T淋巴细胞巨噬细胞链脲霉素

Keywords

diabetes mellitusT lymphocyteMacrophagesStreptozotocin

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