EFFECTS OF SMALL DOSE OF QUINIDINE ON THE ELIMINATION OF ANTIPYRINE IN MAN

Tu Zhiguang et al.

doi:10.13406/j.cnki.cyxb.1990.02.003

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EFFECTS OF SMALL DOSE OF QUINIDINE ON THE ELIMINATION OF ANTIPYRINE IN MAN

更新时间：2024-01-17

- EFFECTS OF SMALL DOSE OF QUINIDINE ON THE ELIMINATION OF ANTIPYRINE IN MAN
- Journal of Chongqing Medical University Issue 2, Pages: 102-105(1990)
- 作者机构：
  
  重庆医科大学药理学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1990.02.003
  CLC：
- Published：1990，
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[1]涂植光,Speirs.C.J..小剂量奎尼丁对安替比林消除的影响[J].重庆医科大学学报,1990(02):102-105.

Tu Zhiguang et al.. EFFECTS OF SMALL DOSE OF QUINIDINE ON THE ELIMINATION OF ANTIPYRINE IN MAN. [J]. Journal of Chongqing Medical University (2):102-105(1990)
[1]涂植光,Speirs.C.J..小剂量奎尼丁对安替比林消除的影响[J].重庆医科大学学报,1990(02):102-105. DOI： 10.13406/j.cnki.cyxb.1990.02.003.

Tu Zhiguang et al.. EFFECTS OF SMALL DOSE OF QUINIDINE ON THE ELIMINATION OF ANTIPYRINE IN MAN. [J]. Journal of Chongqing Medical University (2):102-105(1990) DOI： 10.13406/j.cnki.cyxb.1990.02.003.

摘要

用高效液相法测定了小剂量（5mg）奎尼丁对6名健康受试者唾液中安替比林的药动学参数、尿中安替比林及其代谢物3-羟甲基安替比林、4-羟基安替比林和去甲基安替比林排泄率的影响。结果表明

小剂量奎尼丁对唾液中安替比林的半衰期、消除速率常数、清除率、药一时曲线下面积和表观分布容积等药动学参数均无影响

对尿中安替比林、3-羟甲基安替比林、去甲基安替比林及总代谢物排泄量亦无明显影响

但能减少尿中4-羟基安替比林的排泄量（P<0.05）

Abstract

The effects of single dose (5mg) of quinidine on the pharmacokinetics of antipyri-ne in saliva and the excretion ratios of antipyrine and its three main metabolites in urine were studied on 6 healthy volunteers with HPLC.Quinidine did not affect the antipyrine saliva pharmacokinetrics parameters

half life(t-1/2) .elimination constant(Kel)

clearance rate(Cl)

apparent distribution volume(Vd)and the area under the C-T curve (AUC).had no effects on the urine excreted total amount of antipyrine metabolites and the ratios of antipyrine

3-hydroXymethylantipyrine and norantipyrinc either

but could significantly reduce the urine excretion ratio of 4-hydroXyantipyrine(P<0.05)

关键词

安替比林奎尼丁药代动力学药物相互作用

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