PHAGOCYTIC DYSFUNCTION OF NEUTROPHIL IN DIABETIC RATS INDUCED BY ALLOXAN

Li Qifu et al

doi:10.13406/j.cnki.cyxb.1990.02.002

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PHAGOCYTIC DYSFUNCTION OF NEUTROPHIL IN DIABETIC RATS INDUCED BY ALLOXAN

更新时间：2024-01-17

- PHAGOCYTIC DYSFUNCTION OF NEUTROPHIL IN DIABETIC RATS INDUCED BY ALLOXAN
- Journal of Chongqing Medical University Issue 2, Pages: 99-102(1990)
- 作者机构：
  
  1. 重庆医科大学第一医院内科学教研室
  2. 重庆医科大学第一医院内科学教研室研究生
  3. 重庆医科大学第一医院内科学教研室重庆医科大学第一医院内科学教研室研究生
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1990.02.002
  CLC：
- Published：1990，
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[1]李启富,舒昌达.四氧嘧啶糖尿病大鼠外周血嗜中性粒细胞吞噬功能改变[J].重庆医科大学学报,1990(02):99-102.

Li Qifu et al. PHAGOCYTIC DYSFUNCTION OF NEUTROPHIL IN DIABETIC RATS INDUCED BY ALLOXAN. [J]. Journal of Chongqing Medical University (2):99-102(1990)
[1]李启富,舒昌达.四氧嘧啶糖尿病大鼠外周血嗜中性粒细胞吞噬功能改变[J].重庆医科大学学报,1990(02):99-102. DOI： 10.13406/j.cnki.cyxb.1990.02.002.

Li Qifu et al. PHAGOCYTIC DYSFUNCTION OF NEUTROPHIL IN DIABETIC RATS INDUCED BY ALLOXAN. [J]. Journal of Chongqing Medical University (2):99-102(1990) DOI： 10.13406/j.cnki.cyxb.1990.02.002.

摘要

本文报道四氧嘧啶诱导的糖尿病大鼠外周血嗜中性粒细胞对中华墨汁颗粒的吞噬功能测定

结果显示:（1）糖尿病大鼠嗜中性粒细胞吞噬率和吞噬指数明显降低（P<0.01）;（2）体外试验观察到在高葡萄糖浓度下

正常大鼠嗜中性粒细胞吞噬率和吞噬指数显著下降

并与葡萄糖浓度呈负相关关系（P<0.01）

但相关关系不密切。高血糖可能是糖尿病状态下粒细胞吞噬功能受损的原因之一

Abstract

In this study

phagocytic function of circulating neutrophils from diabetic rats induced by alloXan was investigated .The results showed that

(a)phagccytic rate and index of neutrophils from the diabetic rats significantly decreased(P<0.01); (2)Phagocytic rate and index of neutrophils from normal rats decreased at high blood glucose concentration

and the degree of the reduction was significantly (P<0.01) correlated to glucose levels

but not very closely.Our data suggested that hyperglycemia may be one of the causes that damage the phagocytic function of neutrophils in diabetes mellitus

关键词

糖尿病嗜中性粒细胞吞噬功能四氧嘧啶

Keywords

diabetesNeutrophilsPhagocytic functionalloxan

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