APPLICATION OF LINEAR REGRESSION METHOD OF MULTIWAVELENGTH DATA AND ORTHOGONAL FUNCTIONS SPECTROPHOTOMETRY——DETERMINATION OF SULFAMETHOXAZOLE AND TRIEMETHOPRIM IN CO-TRIMOXAZOLE TABLETS

Shang Jingchuan and Ouyang Yu

doi:10.13406/j.cnki.cyxb.1989.04.023

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APPLICATION OF LINEAR REGRESSION METHOD OF MULTIWAVELENGTH DATA AND ORTHOGONAL FUNCTIONS SPECTROPHOTOMETRY——DETERMINATION OF SULFAMETHOXAZOLE AND TRIEMETHOPRIM IN CO-TRIMOXAZOLE TABLETS

更新时间：2024-01-17

- APPLICATION OF LINEAR REGRESSION METHOD OF MULTIWAVELENGTH DATA AND ORTHOGONAL FUNCTIONS SPECTROPHOTOMETRY——DETERMINATION OF SULFAMETHOXAZOLE AND TRIEMETHOPRIM IN CO-TRIMOXAZOLE TABLETS
- Journal of Chongqing Medical University Issue 4, Pages: 330-333(1989)
- 作者机构：
  
  重庆医科大学化学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.04.023
  CLC：
- Published：1989，
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[1]尚京川,欧阳瑜.多波长数据线性回归法和正交函数分光光度法的应用——复方新诺明片的测定[J].重庆医科大学学报,1989(04):330-333.

Shang Jingchuan and Ouyang Yu. APPLICATION OF LINEAR REGRESSION METHOD OF MULTIWAVELENGTH DATA AND ORTHOGONAL FUNCTIONS SPECTROPHOTOMETRY——DETERMINATION OF SULFAMETHOXAZOLE AND TRIEMETHOPRIM IN CO-TRIMOXAZOLE TABLETS. [J]. Journal of Chongqing Medical University (4):330-333(1989)
[1]尚京川,欧阳瑜.多波长数据线性回归法和正交函数分光光度法的应用——复方新诺明片的测定[J].重庆医科大学学报,1989(04):330-333. DOI： 10.13406/j.cnki.cyxb.1989.04.023.

Shang Jingchuan and Ouyang Yu. APPLICATION OF LINEAR REGRESSION METHOD OF MULTIWAVELENGTH DATA AND ORTHOGONAL FUNCTIONS SPECTROPHOTOMETRY——DETERMINATION OF SULFAMETHOXAZOLE AND TRIEMETHOPRIM IN CO-TRIMOXAZOLE TABLETS. [J]. Journal of Chongqing Medical University (4):330-333(1989) DOI： 10.13406/j.cnki.cyxb.1989.04.023.

摘要

用多波长数据线性回归法和正交函数分光光度法

不经分离直接测定复方新诺明片中磺胺甲基异恶唑（SMZ）和甲氧苄氨嘧啶（TMP）的含量。本法方法简单

操作迅速。磺胺甲基异恶唑的平均回收率为99.72—100.5％

变异系数小于0.48％

甲氧苄氨嘧啶的平均回收率为99.25—99.46％

变异系数小于0.83％。其准确度和精密度能满足制剂分析的要求。

Abstract

The linear regression method of multiwavelength data and orthogonal functions spectropho-tomtry have been used for the determination of sulfamethoxazole and triemethoprim in co-trimo-xazole tablets without any preliminary separation.The methods are simple and rapid.Good results have been obtained. The average recovery of sulfamethoxazole was 99.72-100.5%

with coefficient of variation below 0.48%

and the average recovery of triemethoprim was 99.26-99.46%

with coefficient of variation below 0.83%. The accuracy and precision meet the requirements of analysis of the pharmaceutical preparations

关键词

线性回归法正交函数法复方新诺明片磺胺甲基异恶唑甲氧苄氨嘧啶

Keywords

Linear regression methodOrthogonal functions methodco-trimoxazole tabletsSulfamethoxzoleTriemethoprim

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