THE STUDY ON CHROMOSOME INSTABILITY OF THE PATIENTS WITH RETINOBLASTONA AND THE PARENTS

Peng Huimin et al

doi:10.13406/j.cnki.cyxb.1989.04.017

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THE STUDY ON CHROMOSOME INSTABILITY OF THE PATIENTS WITH RETINOBLASTONA AND THE PARENTS

更新时间：2024-01-17

- THE STUDY ON CHROMOSOME INSTABILITY OF THE PATIENTS WITH RETINOBLASTONA AND THE PARENTS
- Journal of Chongqing Medical University Issue 4, Pages: 317-320(1989)
- 作者机构：
  
  1. 重庆医科大学生物学教研室
  2. 重庆医科大学第一医院眼科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.04.017
  CLC：
- Published：1989，
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[1]彭惠民,郑燕林,汤鼎华.视网膜母细胞瘤患者和双亲染色体不稳定性观察[J].重庆医科大学学报,1989(04):317-320.

Peng Huimin et al. THE STUDY ON CHROMOSOME INSTABILITY OF THE PATIENTS WITH RETINOBLASTONA AND THE PARENTS. [J]. Journal of Chongqing Medical University (4):317-320(1989)
[1]彭惠民,郑燕林,汤鼎华.视网膜母细胞瘤患者和双亲染色体不稳定性观察[J].重庆医科大学学报,1989(04):317-320. DOI： 10.13406/j.cnki.cyxb.1989.04.017.

Peng Huimin et al. THE STUDY ON CHROMOSOME INSTABILITY OF THE PATIENTS WITH RETINOBLASTONA AND THE PARENTS. [J]. Journal of Chongqing Medical University (4):317-320(1989) DOI： 10.13406/j.cnki.cyxb.1989.04.017.

摘要

本文对15例视网膜母细胞瘤（RB）患者

24例患者双亲以及正常对照16人的姊妹染色单体交换（SCE）率、微核（MN）率的观察表明

患者自发、丝裂霉素C（MMC）诱发的SCE率和MN率均与对照有显著差异。本实验为RB患者存在体细胞染色体不稳定性提供了证据

同时讨论了染色体不稳定性与RB发生的关系

Abstract

The frequencies of sister chromatid exchange (SCE) and micronucleus (MN) of peripheral blood lymphocytes were determined in 15 patients with RB

their 24 parents and 16 normal controls.The results showed that the spontaneous

MMC induced SCE and MN rates in patients were significantly higher than those in controls. Therefore

the results provided some positive evidence for chromosome instability in RB patients. The relationship between chromosome instability and the origin of RB was also discussed

关键词

视网膜母细胞瘤染色体姊妹染色单体交换微核

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