ARREST OF IMMUNOGLOBULIN CLASS AND SUBCLASS SWITCHING IN COMMON VARIABLE IMMUNODEFICIENCY……Ⅱ. OBSERVATION IN VIVO

Li Chengrong et al.

doi:10.13406/j.cnki.cyxb.1989.04.006

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ARREST OF IMMUNOGLOBULIN CLASS AND SUBCLASS SWITCHING IN COMMON VARIABLE IMMUNODEFICIENCY……Ⅱ. OBSERVATION IN VIVO

更新时间：2024-01-17

- ARREST OF IMMUNOGLOBULIN CLASS AND SUBCLASS SWITCHING IN COMMON VARIABLE IMMUNODEFICIENCY……Ⅱ. OBSERVATION IN VIVO
- Journal of Chongqing Medical University Issue 4, Pages: 284-287(1989)
- 作者机构：
  
  1. 重庆医科大学儿科医院
  2. 重庆医科大学华盛顿大学医学院儿科免疫实验室教授
  3. 重庆医科大学名誉教授
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.04.006
  CLC：
- Published：1989，
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[1]李成荣,杨锡强,Hans D. Ochs.普通变异型免疫缺陷症的Ig类别及其亚类转换障碍——Ⅱ.体内观察[J].重庆医科大学学报,1989(04):284-287.

Li Chengrong et al.. ARREST OF IMMUNOGLOBULIN CLASS AND SUBCLASS SWITCHING IN COMMON VARIABLE IMMUNODEFICIENCY……Ⅱ. OBSERVATION IN VIVO. [J]. Journal of Chongqing Medical University (4):284-287(1989)
[1]李成荣,杨锡强,Hans D. Ochs.普通变异型免疫缺陷症的Ig类别及其亚类转换障碍——Ⅱ.体内观察[J].重庆医科大学学报,1989(04):284-287. DOI： 10.13406/j.cnki.cyxb.1989.04.006.

Li Chengrong et al.. ARREST OF IMMUNOGLOBULIN CLASS AND SUBCLASS SWITCHING IN COMMON VARIABLE IMMUNODEFICIENCY……Ⅱ. OBSERVATION IN VIVO. [J]. Journal of Chongqing Medical University (4):284-287(1989) DOI： 10.13406/j.cnki.cyxb.1989.04.006.

摘要

以新抗原噬菌体174（φ×174）免疫25例普通变异型免疫缺陷（CVI）病人

以观察其体内免疫球蛋白（Ig）及其亚类转换功能。24例正常成人作为对照组。结果示25例人

仅4例能完全从IgM转换到IgG

9例仅产生IgM

5例IgM+IgG

+IgG

6例IgM+IgG

+IgG

+IgG2。上述发现进一步表明CVI的低丙种球蛋白血症系由沿CH基因5′—3′顺序的Ig类别及其亚类转换障碍所致

Abstract

The proceeding of immunoglobulin class and subclass switching in 25 patients of common variable immunodeficiency was observed in vivo by using of vaccination with new-antigen bacteria-phage 174 (φx 174). 24 normal adults served as control. The pattern of anti-?x174 specific antibody response was as follows: IgM was presented first with decreasing rapidly

and IgG was coming late maintaining its high level long. The sequence of IgG subclass productions was in order of IgG3 and IgG1

IgG2

IgG4. There were special profiles of antibody response to φx174 in CVI patients: (l)class swithing defects: only IgM production in 9

IgM + + IgG3+IgGi in 5

IgM+IgG3 +IgGi + IgG2 in 6

and swithing from IgM to IgG4 ia only 4 cases; (2)the value of antibody response was low. Such fingings further indicate that the hypo-gammaglobulinemia of CVI resulted from defects in different levels of Ig class and subclass swithing along the 5’-3’ order of CH genes

关键词

普通变异型免疫缺陷病噬菌体174特异性抗体免疫球蛋白类别/亚类转换

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