STUDIES ON GABA-T AND ITS INHIBITOR IN MICE WITH HEPATIC ENCEPHALOPATHY

Jiang Xiaoqiu

doi:10.13406/j.cnki.cyxb.1989.04.004

您当前的位置：

首页 >

文章列表页 >

STUDIES ON GABA-T AND ITS INHIBITOR IN MICE WITH HEPATIC ENCEPHALOPATHY

更新时间：2024-01-17

- STUDIES ON GABA-T AND ITS INHIBITOR IN MICE WITH HEPATIC ENCEPHALOPATHY
- Journal of Chongqing Medical University Issue 4, Pages: 275-280(1989)
- 作者机构：
  
  重庆医科大学生化教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.04.004
  CLC：
- Published：1989，
扫描看全文
[1]蒋晓秋,王征泰.肝性脑病小鼠GABA—T及其抑制物的研究[J].重庆医科大学学报,1989(04):275-280.

Jiang Xiaoqiu. STUDIES ON GABA-T AND ITS INHIBITOR IN MICE WITH HEPATIC ENCEPHALOPATHY. [J]. Journal of Chongqing Medical University (4):275-280(1989)
[1]蒋晓秋,王征泰.肝性脑病小鼠GABA—T及其抑制物的研究[J].重庆医科大学学报,1989(04):275-280. DOI： 10.13406/j.cnki.cyxb.1989.04.004.

Jiang Xiaoqiu. STUDIES ON GABA-T AND ITS INHIBITOR IN MICE WITH HEPATIC ENCEPHALOPATHY. [J]. Journal of Chongqing Medical University (4):275-280(1989) DOI： 10.13406/j.cnki.cyxb.1989.04.004.

摘要

采用修改的

C-GABA法测定小鼠脑、肝、肾组织GABA-T活性

方法灵敏可靠。氨基半乳糖诱发的肝性脑病小鼠肝脏GABA-T活性明显降低。首次报道了小鼠肝匀浆上清液对脑GABA-T有抑制作用

经加热、盐析、Sephadex G-150层析

抑制活性在洗脱前段。提示严重肝损害时肝脏对GABA的分解代谢降低

正常肝细胞中存在有对脑GABA-T有抑制作用的分子量较大的物质

Abstract

The GABA-T activities of mice brain

liver and kidney were determined by the modified labeled "C-GABA method

and the method has been proved sensitive and feasible.Hepatic encephalopathy in galactosamine-induced mice was associated with a marked decrease of GABA-T activity of liver. The inhibition of brain GABA-T activity by the LHS of normal mice was demonstrated for the first time.After heat denaturation at 55℃ and ammonium sulfate fractionation

the elution pattern of Sephadex G-150 gel- filtration showed the inhibitory activity localized just behind the exclusive volume. These findings indicate a decrease of GABA catabolism in liver in severe liver injury

and there is a kind of GABA-T inhibitor in LHS with rather big molecular weight

关键词

GABA-TGABA-T抑制物GABA肝性脑病

Keywords

GABA-TGABA-T inhibitorGABAhepatic encephalopathy

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

CHANGE OF BRAIN UPTAKE OF BLOOD GABA IN EXPERIMENTAL HEPATIC ENCEPHALOPATHY IN MICE

THE IN VITRO INHIBITION OF CEREBRAL GABA DEGRADATION BY THE LIVER HOMOGENATE SUPERNATANT OF MICE

A controlled study of intermittent and regular administration of rifaximin for the prevention of hepatic encephalopathy and all-cause hospitalisation

DETERMINATION AND CLINICAL SIGNIFICANCE OF CONCENTRATIONS OF PLASMA AMMONIA, SERUM TRYPTOPHAN, SEROTONIN AND 5-HYDROXYINDOLACETIC ACID IN PATIENTS WITH HEPATIC ENCEPHALOPATHY

The influence of noise on learning memory behaviors in and expression of GABA neurons in hippocampus

Related Author

Department of Biochemistry Li Qian Wang Zhengtai

王征泰

He Tongchaun

Wang Zhengtai

Chen Jia

Xiao Xiao

Tong Jin

Wan Xiaoqiang

Related Institution

重庆医科大学生化教研室

Department of Gastroenterology，Chongqing Fourth People's Hospital/Chongqing University Central Hospital

Department of Internal Medicine, The Second Hospital

重庆医科大学第二医院研究生

重庆医科大学第二医院重庆医科大学第二医院研究生

⁰