COMBINED ASSAY OF SERUM TUMOR ENZYME MARKERS IN THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA

Shen Wei & Shen Dingming

doi:10.13406/j.cnki.cyxb.1989.04.001

您当前的位置：

首页 >

文章列表页 >

COMBINED ASSAY OF SERUM TUMOR ENZYME MARKERS IN THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA

更新时间：2024-01-17

- COMBINED ASSAY OF SERUM TUMOR ENZYME MARKERS IN THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA
- Journal of Chongqing Medical University Issue 4, Pages: 261-266(1989)
- 作者机构：
  
  重庆医科大学第二医院
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.04.001
  CLC：
- Published：1989，
扫描看全文
[1]沈薇,沈鼎明.多项血清肿瘤酶标志物联合检测对原发性肝癌诊断的价值[J].重庆医科大学学报,1989(04):261-266.

Shen Wei & Shen Dingming. COMBINED ASSAY OF SERUM TUMOR ENZYME MARKERS IN THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA. [J]. Journal of Chongqing Medical University (4):261-266(1989)
[1]沈薇,沈鼎明.多项血清肿瘤酶标志物联合检测对原发性肝癌诊断的价值[J].重庆医科大学学报,1989(04):261-266. DOI： 10.13406/j.cnki.cyxb.1989.04.001.

Shen Wei & Shen Dingming. COMBINED ASSAY OF SERUM TUMOR ENZYME MARKERS IN THE DIAGNOSIS OF HEPATOCELLULAR CARCINOMA. [J]. Journal of Chongqing Medical University (4):261-266(1989) DOI： 10.13406/j.cnki.cyxb.1989.04.001.

摘要

本文对59例原发性肝癌（HCC）和97例其他肝病及消化道肿瘤患者进行了血清肿瘤酶标志物的联合测定。结果显示HCC组的r-谷氨酰转肽酶同工酶、碱性磷酸酶同工酶、醛缩酶同工酶及血清α-L-岩藻糖苷酶的活力均较正常组显著增高（P<0.01）

四种酶联合检测对AFP（一）HCC的诊断阳性率为80％

与AFP联合检测对HCC总的诊断检出率达95.7％

Abstract

In order to evaluate combined serum tumor enzyme determinations in the diagnosis of hepatocellular carcinoma (HCC)

four tumor markers including gamma-glutamyl tran- speptidase isoenzyme (r-GT-II)

alkaline phosphatese isoenzyme (ALP-I)

the ratio of the two aldolase activities

fructose-1

6-diphosphoaldolase and fructose-1-phosphoaldo-lase (FDP/FIP) and a-L-fucosidase (AFU) were concomitantly determined in 59 patients with HCC

97 patients with various liver diseases and gastrointestinal tumors. The results revealed that: (l)r-GT-II

ALP-I

FDP/FIP and AFU level were increased significantly in HCC (P<0.01); (2) The diagnostic sensitivity and specificity of these markers in HCC were r-GT-II(79.7%)>AFU(78.8%)>FDP/FIP(61%)>ALP-I(16.95%) and ALP-I(100%) >r-GT-II(92.l%)>AFU(90.9%)>FDP/FIP (88.8%)

respectively; (3) The diagnostic positivity of combination assay was 80.0% in low or negative AFP producing HCC

while 95.7% in those with elevated AFP. Our data suggested that the combination assay of serum tumor enzyme markers was valuable in the diagnosis of HCC

especially in low or negative AFP HCC patients

关键词

原发性肝癌r-谷氨酰转肽酶同工酶碱性磷酸酶同工酶α-L-岩藻糖苷酶醛缩酶同工酶

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

EVALUATION OF SERUM FUCOSYLATED AFP ASSAY IN THE DIAGNOSIS OF PRIMARY HEPATIC CARCINOMA

Evaluation of serum lectin-reactive α-fetoprotein affinity blotting method and the qualitative,quantitative analysis of γ-glutamyl transpeptidase isozyme Ⅱ in the diagnosis of primary hepatic carcinoma

Related Author

左国庆

沈鼎明

庞春梅

沈鼎明

王景

Related Institution

重庆医科大学第二医院内科

重庆医科大学第二医院内科研究生

重庆医科大学第二医院内科重庆医科大学第二医院内科研究生

广州市红十字会医院消化内科

重庆医科大学第二临床学院消化内科

⁰