IMMUNOGLOBULIN CLASS AND SUBCLASS SWITCHING DEFECTS IN COMMON VARIABLE IMMUNODEFICIENCY——Ⅰ: OBSERVATIONS IN VITRO

Li Chengrong; Yang Xiqiang; Hans D. Ochs

doi:10.13406/j.cnki.cyxb.1989.03.013

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IMMUNOGLOBULIN CLASS AND SUBCLASS SWITCHING DEFECTS IN COMMON VARIABLE IMMUNODEFICIENCY——Ⅰ: OBSERVATIONS IN VITRO

更新时间：2024-01-17

- IMMUNOGLOBULIN CLASS AND SUBCLASS SWITCHING DEFECTS IN COMMON VARIABLE IMMUNODEFICIENCY——Ⅰ: OBSERVATIONS IN VITRO
- Journal of Chongqing Medical University Issue 3, Pages: 214-217(1989)
- 作者机构：
  
  1. 重庆医科大学儿科医院
  2. 美国华盛顿大学医学院儿科免疫实验室重庆医科大学名誉教授
  3. 重庆医科大学儿科医院美国华盛顿大学医学院儿科免疫实验室重庆医科大学名誉教授
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.03.013
  CLC：
- Published：1989，
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[1]李成荣,杨锡强,Hans D. Ochs.普通变异型免疫缺陷症的Ig类别及其亚类转换障碍——Ⅰ:体外观察[J].重庆医科大学学报,1989(03):214-217.

Li Chengrong, Yang Xiqiang, Hans D. Ochs. IMMUNOGLOBULIN CLASS AND SUBCLASS SWITCHING DEFECTS IN COMMON VARIABLE IMMUNODEFICIENCY——Ⅰ: OBSERVATIONS IN VITRO. [J]. Journal of Chongqing Medical University (3):214-217(1989)
[1]李成荣,杨锡强,Hans D. Ochs.普通变异型免疫缺陷症的Ig类别及其亚类转换障碍——Ⅰ:体外观察[J].重庆医科大学学报,1989(03):214-217. DOI： 10.13406/j.cnki.cyxb.1989.03.013.

Li Chengrong, Yang Xiqiang, Hans D. Ochs. IMMUNOGLOBULIN CLASS AND SUBCLASS SWITCHING DEFECTS IN COMMON VARIABLE IMMUNODEFICIENCY——Ⅰ: OBSERVATIONS IN VITRO. [J]. Journal of Chongqing Medical University (3):214-217(1989) DOI： 10.13406/j.cnki.cyxb.1989.03.013.

摘要

采用美洲商陆（PWM）或EB病毒（EBV）体外诱导26例常见变异型免疫缺陷病（CVI）外周血淋巴细胞产生免疫球蛋白（Ig）及其亚类的能力

结果显示所有病例均不能产生全部Ig及其亚类

Abstract

Ability of itnmunoglobulin production of peripheral blood lymphocytes from 26 patients with common variable immunodeficiency was observed. The results showed that none of these cases can produce all kinds of Ig classes and subclasses: among these cases induced by PWM

no Ig production at all in 8

only IgM in 5

IgM-IgG3-IgG1 in 7

IgM-IgG3-IgG1-IgA1-IgG2 in 2

no regulation for Ig production in 4 cases; as induced by EBV

no Ig production in 1

only IgM in 9. stagnated at the level of IgM-IgG3-IgG1 in 11

switching to IgM-IgG3-TgG1-IgA1 in 2

up to IgM-IgG3-IgGl-IgAl-IgG2 in l.and only IgG3 in another case. There was no case produing IgG4 and IgA2. Such finding of the pattern of Ig production in vitro could imply that the expression of Ig CH genes is arrested by class switching defects along CH genes downstream from 5’ to 3’ sequence

关键词

普通变异型免疫缺陷病免疫球蛋白类别/亚类转换

Keywords

Common Variable ImmunodeficiencyImmunoglo bulin Class and Subclass Switching

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