ESTABLISHMENT OF RAT MODEL OF PNEUMO CYSTIS PNEUMONIA AND PATHOGENIC AND PATHOLOGICAL OBSERVATIONS

Chen Yatang; et al.

doi:10.13406/j.cnki.cyxb.1989.03.003

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ESTABLISHMENT OF RAT MODEL OF PNEUMO CYSTIS PNEUMONIA AND PATHOGENIC AND PATHOLOGICAL OBSERVATIONS

更新时间：2024-01-17

- ESTABLISHMENT OF RAT MODEL OF PNEUMO CYSTIS PNEUMONIA AND PATHOGENIC AND PATHOLOGICAL OBSERVATIONS
- Journal of Chongqing Medical University Issue 3, Pages: 181-183(1989)
- 作者机构：
  
  1. 重庆医科大学传染病寄生虫病研究所
  2. 重庆医科大学病理解剖教研室
  3. 重庆医科大学电镜室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.03.003
  CLC：
- Published：1989，
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[1]陈雅棠,刘约翰,沈际琨,唐宜,王小根.大鼠肺孢子虫肺炎动物模型建立及病原学病理学观察[J].重庆医科大学学报,1989(03):181-183+261-262.

Chen Yatang, et al.. ESTABLISHMENT OF RAT MODEL OF PNEUMO CYSTIS PNEUMONIA AND PATHOGENIC AND PATHOLOGICAL OBSERVATIONS. [J]. Journal of Chongqing Medical University (3):181-183(1989)
[1]陈雅棠,刘约翰,沈际琨,唐宜,王小根.大鼠肺孢子虫肺炎动物模型建立及病原学病理学观察[J].重庆医科大学学报,1989(03):181-183+261-262. DOI： 10.13406/j.cnki.cyxb.1989.03.003.

Chen Yatang, et al.. ESTABLISHMENT OF RAT MODEL OF PNEUMO CYSTIS PNEUMONIA AND PATHOGENIC AND PATHOLOGICAL OBSERVATIONS. [J]. Journal of Chongqing Medical University (3):181-183(1989) DOI： 10.13406/j.cnki.cyxb.1989.03.003.

摘要

纯系Wistar大鼠皮下注射醋酸可的松25mg/次

每周2次

用药7周即可成功诱发大鼠肺孢子虫肺炎。相差显微镜直接镜检、姬姆萨氏染色（Giemsa’s stain）、六亚甲基四胺银染色（GMS stain）和亚甲胺蓝染色（TBO stain）均可检出包囊。其中六亚甲基四胺银染色可显示囊壁特征性的括弧样结构

具有确诊价值。病理改变主要为肺泡间隔增厚和淋巴细胞、单核细胞浸润

肺泡中少量蜂窝状渗出物。对肺孢子虫的滋养体、囊子前期和囊子的超微结构进行了电镜观察

Abstract

Seventeen wistar rats were injected with cortisone acetate twice a week subcuteneously. After 7 weeks

pneumocystis pneumonia of rats was induced successfully. The cysts of Pneumocyst carinii were identified by phase-contrast microscope

Giemsa’s stain

Gomori’s methenamine silver nitrate stain and Chalvardjian’s toluidine blue-O stain simultaneously. A characteristic parentheses-like structure was found by Gomori’s stain in cyst wall. This structure has important value for differential diagnosis of pneumocystis pneumonia. The pathological changes were thickening of alveolar wall and infiltration of lymphocytes and monocytes. A few of honeycomb-like infiltration were found in the alveolar cavity. The Ultrastructures of trophozoite

precyst and cyst were observed by transmission electron microscope

关键词

卡氏肺孢子虫肺炎六亚甲基四胺银染色括弧样结构透射电镜

Keywords

Pneumocystis carinii pneumoniaGomori’s methenamine silver nitrate stainParentheses-like structureTransmission electron microscope

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