THE IN VITRO INHIBITION OF CEREBRAL GABA DEGRADATION BY THE LIVER HOMOGENATE SUPERNATANT OF MICE

He Tongchaun; Wang Zhengtai

doi:10.13406/j.cnki.cyxb.1989.03.002

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THE IN VITRO INHIBITION OF CEREBRAL GABA DEGRADATION BY THE LIVER HOMOGENATE SUPERNATANT OF MICE

更新时间：2024-01-17

- THE IN VITRO INHIBITION OF CEREBRAL GABA DEGRADATION BY THE LIVER HOMOGENATE SUPERNATANT OF MICE
- Journal of Chongqing Medical University Issue 3, Pages: 176-180(1989)
- 作者机构：
  
  重庆医科大学生化教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.03.002
  CLC：
- Published：1989，
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[1]何通川,王征泰.小鼠肝匀浆对脑GABA降解的抑制作用[J].重庆医科大学学报,1989(03):176-180.

He Tongchaun, Wang Zhengtai. THE IN VITRO INHIBITION OF CEREBRAL GABA DEGRADATION BY THE LIVER HOMOGENATE SUPERNATANT OF MICE. [J]. Journal of Chongqing Medical University (3):176-180(1989)
[1]何通川,王征泰.小鼠肝匀浆对脑GABA降解的抑制作用[J].重庆医科大学学报,1989(03):176-180. DOI： 10.13406/j.cnki.cyxb.1989.03.002.

He Tongchaun, Wang Zhengtai. THE IN VITRO INHIBITION OF CEREBRAL GABA DEGRADATION BY THE LIVER HOMOGENATE SUPERNATANT OF MICE. [J]. Journal of Chongqing Medical University (3):176-180(1989) DOI： 10.13406/j.cnki.cyxb.1989.03.002.

摘要

用偶联酶学荧光分光光度法测定脑GABA-T活性

在小鼠肝昏迷模型中证实了Ferenci等报道的肝昏迷兔血清能抑制脑GABA降解的实验结果

并首次报道了正常及肝昏迷小鼠LHS对脑GABA降解也有抑制作用。说明正常肝细胞中存在有对脑GABA降解有抑制作用的物质。它是肝脏特有的或主要存在于肝脏。对GABA降解抑制物参与肝昏迷发病机制的可能性进行了讨论。

Abstract

The cerebral GABA-T activity of mice was determined by the modified coupled-enzyme spectroflourimctry

and the method was proved stable and feasible. The cerebral GABA degradation of mice in vitro was inhibited by the sera from the mice with hepatic coma induced by galactosamine. The supernatant of liver homogenate of both control and hepatic coma groups can inhibit the cerebral GABA degradation too. The inhibitory capacity is proportional to the volume of LHS added in certain conditions

and reaches a maximum inhibitory rate of 80%. The inhibition can not be relieved by pyridoxal phosphate.The inhibitory effector of cerebral GABA degradation has been regarded as liver specific or mainly presented in the liver since no appreciable inhibition was found after the addition of the supernaiants of kidney

heart

lung and spleen homogenates. The possible contribution of GABA degradation inhibition by LHS to the pathogenesis of hepatic encephalopathy has also been discussed

关键词

GABA降解GABA降解抑制GABA-T肝性脑病

Keywords

GABA DegradationInhibiton of GABA DegradationGABA-Thepatic encephalopathy

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