STUDIES ON THE CHANGES OF ANTIBIOTIC RESISTANCE OF SALMONELLA AND THEIR THERAPEUTIC IMPLICATIONS IN CHONGQING DISTRICT

Du Jizhao; Wang Qinan et al

doi:10.13406/j.cnki.cyxb.1989.01.010

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STUDIES ON THE CHANGES OF ANTIBIOTIC RESISTANCE OF SALMONELLA AND THEIR THERAPEUTIC IMPLICATIONS IN CHONGQING DISTRICT

更新时间：2024-01-17

- STUDIES ON THE CHANGES OF ANTIBIOTIC RESISTANCE OF SALMONELLA AND THEIR THERAPEUTIC IMPLICATIONS IN CHONGQING DISTRICT
- Journal of Chongqing Medical University Issue 1, Pages: 29-33(1989)
- 作者机构：
  
  重庆医科大学第一医院传染病学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.01.010
  CLC：
- Published：1989，
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[1]杜继昭,王其南,严思壮,段明纲,倪小毅,郑行萍.重庆地区沙门氏菌耐药变迁及临床疗效观察[J].重庆医科大学学报,1989(01):29-33.

Du Jizhao, Wang Qinan et al. STUDIES ON THE CHANGES OF ANTIBIOTIC RESISTANCE OF SALMONELLA AND THEIR THERAPEUTIC IMPLICATIONS IN CHONGQING DISTRICT. [J]. Journal of Chongqing Medical University (1):29-33(1989)
[1]杜继昭,王其南,严思壮,段明纲,倪小毅,郑行萍.重庆地区沙门氏菌耐药变迁及临床疗效观察[J].重庆医科大学学报,1989(01):29-33. DOI： 10.13406/j.cnki.cyxb.1989.01.010.

Du Jizhao, Wang Qinan et al. STUDIES ON THE CHANGES OF ANTIBIOTIC RESISTANCE OF SALMONELLA AND THEIR THERAPEUTIC IMPLICATIONS IN CHONGQING DISTRICT. [J]. Journal of Chongqing Medical University (1):29-33(1989) DOI： 10.13406/j.cnki.cyxb.1989.01.010.

摘要

本文报道了重庆地区1984～1988年沙门氏菌对32种抗菌药的敏感度试验、30年来的耐药变迁及伤寒与耐药伤寒的临床疗效观察。表明耐药伤寒杆菌对常用于治疗伤寒的抗生素如氯霉素、SMZ/TMP、氨苄青霉素及其它药物产生了不同程度的耐药性

对近年来的新抗菌药如喹诺酮类药物及第三代头孢菌素则很敏感

Abstract

This paper reports the changes in susceptibility of Salmonella spp. to 32 antimicrobial agents from 1959 to 1988. The clinical observation on the treatment of typhoid fever caused by drug-sensitive and resistant strains of S. typhi arc also reported. Resistant Salmonella began to appear from the year of 1986. The in vitro studies indicated that drug-resistant S. typhi were resistant to commonly anti-typhoid agents such as chloramphenicol

SMZ/TMP

ampicillin and other drugs

but were very sensitive to new quinolones and the third generation cephalosporins. The .therapeutic effects correlate well with the in vitro sensitivity tests. Typhoids caused by drug-sensitive strains responded well when treated with chloramphenicol

SMZ/TMP or ampicillin

while those caused by resistant strains only responded well to norfloxacin or its combi-nation with other drugs

关键词

沙门氏菌耐药变迁耐药伤寒

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