PHARMACOKINETICES OF RANITIDINE IN NORMAL SUBJECTS

doi:10.13406/j.cnki.cyxb.1989.01.007

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PHARMACOKINETICES OF RANITIDINE IN NORMAL SUBJECTS

更新时间：2024-01-17

- PHARMACOKINETICES OF RANITIDINE IN NORMAL SUBJECTS
- Journal of Chongqing Medical University Issue 1, Pages: 22-25(1989)
- 作者机构：
  
  1. 重庆医科大学检验系
  2. 重庆医科大学第一医院临床药理研究室
  3. 重庆医科大学第一医院麻醉科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.01.007
  CLC：
- Published：1989，
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[1]严怡怡,叶运奎,袁泰先,朱治本,陈萍,蒋夏.正常人口服雷尼替丁的药代动力学研究[J].重庆医科大学学报,1989(01):22-25.

PHARMACOKINETICES OF RANITIDINE IN NORMAL SUBJECTS. [J]. Journal of Chongqing Medical University (1):22-25(1989)
[1]严怡怡,叶运奎,袁泰先,朱治本,陈萍,蒋夏.正常人口服雷尼替丁的药代动力学研究[J].重庆医科大学学报,1989(01):22-25. DOI： 10.13406/j.cnki.cyxb.1989.01.007.

PHARMACOKINETICES OF RANITIDINE IN NORMAL SUBJECTS. [J]. Journal of Chongqing Medical University (1):22-25(1989) DOI： 10.13406/j.cnki.cyxb.1989.01.007.

摘要

本文采用高效液相色谱法测定血药浓度

对10名健康自愿者

口服雷尼替丁胶囊的药代动力学进行了研究。药时曲线均符合血管外给药开放性一室模型

所得参数与国内外报道的数据在统计学上无明显差异（P>0.05）

Abstract

The pharmacokinetics of ranitidine was studied with the method of high performance li-quid chromatography in 10 healthy volunteers. The subjects were given a single dose of ranitidine 150mg (one capsule) orally. The serum concentration-time curves showed that one-compartment open model could be used in all subjects. The equation of mean serum conccentration was and with following pharmacokinetic parameters: (hr)

and There were no statistically significant differences between the

kinetic parameters of reported articles and ours

关键词

雷尼替丁药代动力学高效液相色谱法

Keywords

ranitidinepharmacokinetieshigh performance liquid chromatography

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Related Author

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叶运奎

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严怡怡

Related Institution

Department of Pharmacy,the China Aviation Industrial Hospital

Department of Pharmacy,The First Affiliated Hospital of Chongqing Medical University

重庆医科大学检验系

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