THE STUDY OF LYMPHOKINE ACTIVITIES IN PRIMARY HUMORAL IMMUNODEFICIENCIES

Li Chengrong; Yang xiqiang Hans D .Ochs

doi:10.13406/j.cnki.cyxb.1989.01.004

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THE STUDY OF LYMPHOKINE ACTIVITIES IN PRIMARY HUMORAL IMMUNODEFICIENCIES

更新时间：2024-01-17

- THE STUDY OF LYMPHOKINE ACTIVITIES IN PRIMARY HUMORAL IMMUNODEFICIENCIES
- Journal of Chongqing Medical University Issue 1, Pages: 9-12(1989)
- 作者机构：
  
  1. 重庆医科大学儿科医院
  2. 美国华盛顿大学医学院儿科免疫实验室教授重庆医科大学名誉教授
  3. 重庆医科大学儿科医院美国华盛顿大学医学院儿科免疫实验室教授重庆医科大学名誉教授
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1989.01.004
  CLC：
- Published：1989，
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[1]李成荣,杨锡强,Hans D.Ochs.原发性体液免疫缺陷病的淋巴因子活性探讨[J].重庆医科大学学报,1989(01):9-12.

Li Chengrong, Yang xiqiang Hans D .Ochs. THE STUDY OF LYMPHOKINE ACTIVITIES IN PRIMARY HUMORAL IMMUNODEFICIENCIES. [J]. Journal of Chongqing Medical University (1):9-12(1989)
[1]李成荣,杨锡强,Hans D.Ochs.原发性体液免疫缺陷病的淋巴因子活性探讨[J].重庆医科大学学报,1989(01):9-12. DOI： 10.13406/j.cnki.cyxb.1989.01.004.

Li Chengrong, Yang xiqiang Hans D .Ochs. THE STUDY OF LYMPHOKINE ACTIVITIES IN PRIMARY HUMORAL IMMUNODEFICIENCIES. [J]. Journal of Chongqing Medical University (1):9-12(1989) DOI： 10.13406/j.cnki.cyxb.1989.01.004.

摘要

以CVI等原发性免疫缺陷病为模型

探讨IFN-r、BCGF、BCDF及IL-2四种淋巴因子缺陷在原发性体液免疫缺陷病中的作用。结果示75.9％。的CVI病人（22/29）有一种或多种淋巴因子缺陷

其中分别为16例IFN-r、15例BCGF、7例BCDF及13例IL-2降低。仅4例病人四种淋巴因子同时缺陷。13例XLA中无1例因巴因子低于正常对照组范围。1例AT体外IFN-r、BCGF及IL-2分泌缺陷。1例高IgM血症患者BCGF降低。上述结果表明淋巴因子缺陷与体液免疫缺陷病的发病机理有一定关系

Abstract

The role of defective lymphokines(IFN-r

BCGF

BCDF

IL-2)in primary humoral immunodeficient patients were studied. One or four kinds of lymphokines were deficient in 75.9% of CVI(22/29) as comparing with normal control

including the impaired production of IL-2 in 13

BCGF in 15

BCDF in 7 and IFN-r in 16 cases respectively. Only 4 cases of CVI had all defect of 4 lymphokines. Lymphokines in 13 cases with XLA were completely normal One case of AT had defect of IFN-r.BCGF. and IL-2 in vitro

and one case of hyper-Igm syndrome had deficient BCGF. These results suggest that abnormality of lymphokines are involved in the pathogcnesis of some primary humoral immunodeficiencies

but not other

and that lyuphokines are sen-thesized by different subsets of T cell or regulated by independent mechanisms

关键词

原发性体液免疫缺陷病IFN-rBCGFBCDFIL-2

Keywords

primary humoral immunodefienciesBCGFBCDFIFN-rIL-2

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