Up to now no specific therapy is available in thalassemia. With transfusion therapy patients often suffer its consequences of chronic iron overload and multiple endocrine deficiencis. But no report is seen in our country. We detected Serum T3

T4 TSH corticosterol(CS)

ensulin (Ins) and serum ferritin (FS) of 33 cases with thalassemias and control group SF levels of patients are clearly higher (101.80±97.50ng/ml vs. 34.73±18.75ng/ml

p<0.001)and T3(1.01±0.33ng/ml)

T4(11.58±3.72ug/dl) were remarkably lower than control group. It iuggested thyroids of them were involved.The relation of serum TSH change betwveen patients and control group had no difference. Increasing serum CS levels of patients may be due to adrenal lesion and provocate reaponse of hypothalamic pituitary-adrenal axis.Serum Ins change had no significant differences in two groups.It concluded that the endocrinologic changes in thalassemia could be secondary to the effects chronic iron loading

chronic anemia and repeated infection. So it is important for us to correct the anemia

decrease the iron loading and prevent infections disease for thalassemia patients