PHOTOMETRIC DETERMINATION OF BLOOD CHLORPROMAZINE LEVEL WITH IONEXCHANGE RESIN COLUMN PROCEDURE

doi:10.13406/j.cnki.cyxb.1988.02.023

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PHOTOMETRIC DETERMINATION OF BLOOD CHLORPROMAZINE LEVEL WITH IONEXCHANGE RESIN COLUMN PROCEDURE

更新时间：2024-01-17

- PHOTOMETRIC DETERMINATION OF BLOOD CHLORPROMAZINE LEVEL WITH IONEXCHANGE RESIN COLUMN PROCEDURE
- Journal of Chongqing Medical University Issue 2, Pages: 154-156(1988)
- 作者机构：
  
  重庆医科大学化学教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1988.02.023
  CLC：
- Published：1988，
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[1]姜靖亚,吕余庆.用离子交换树脂柱式法光度测定血液中盐酸氯丙嗪[J].重庆医科大学学报,1988(02):154-156.

PHOTOMETRIC DETERMINATION OF BLOOD CHLORPROMAZINE LEVEL WITH IONEXCHANGE RESIN COLUMN PROCEDURE. [J]. Journal of Chongqing Medical University (2):154-156(1988)
[1]姜靖亚,吕余庆.用离子交换树脂柱式法光度测定血液中盐酸氯丙嗪[J].重庆医科大学学报,1988(02):154-156. DOI： 10.13406/j.cnki.cyxb.1988.02.023.

PHOTOMETRIC DETERMINATION OF BLOOD CHLORPROMAZINE LEVEL WITH IONEXCHANGE RESIN COLUMN PROCEDURE. [J]. Journal of Chongqing Medical University (2):154-156(1988) DOI： 10.13406/j.cnki.cyxb.1988.02.023.

摘要

<正>氯丙嗪是治疗精神病最有效的药物之一.近年来建立了高效液相色谱法和放射免疫法等较灵敏方法

但前者所用的仪器价格昂贵

不易普及推广.Forrest用离子交换树脂静态加热过滤处理的方法测定尿中氯丙嗪

简便易行

但空白值高

重复性较差.经作者将其改进成柱式法后

然后进

Abstract

The ionexchange-photometric method

suggested by Forrest for the quantisation of urinary chlorpromazine

was modified by means of using a column procedure and room temperature colour development and applied to the blood sample. Both the sensitivity and the reproducibility were improved. The detection limit is 1μg of chlorprornazine hydrochloride per i ml serum. Lambert-Beer’s law is obeyed for up to 40μg of chlorpromazine hydrochloride. The blood level of the drug was correlated with the dosage and the curative effect

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