Diabetes insipidus(DI) of 52 cases with various clinical patterns were analysed for ho-spitaliztion children from 1956 to 1968. Incidence of DI is significantly higher last 10 years than passing 20 years (p<0.01). Primary pituitary diabetes insipidus (PPDI) 30 cases

secondary pituitary diabetes insipdus (SPDI) 22 cases

onset of the disease age and sex were not been significant different on two group patients (p>0.05). Most of the patients clinical symptom had manifested from preschool child or school child

All patients had excessive polyuria

polydipsia and urine SP gr<1.006. Most of PPDI were physical normal

but SPDI often had found primary disease physical non-normal.31 cases DI were followed up 11 months to 18 years (mean 8 years)

PPDI 15 cases

SPDI 16 cases. PPDI were maintenance treated with Vasopressini Tannes Oleosa (VPTO)

result are very well; Primary disease of SPDI were eradicated and gave appropriate treated with VPTO

result are well also

only 2 cases died (6.5%)