CHROMOSOME ANALYSIS IN 81 COUPLES OF HABITUAL ABORTION. [J]. Journal of Chongqing Medical University (1):48-50(1988) DOI: 10.13406/j.cnki.cyxb.1988.01.015.
CHROMOSOME ANALYSIS IN 81 COUPLES OF HABITUAL ABORTION
摘要
本文对81对习惯性流产夫妇进行了染色体研究
发现4例染色体异常
其中3例为相互易位携带者
1例为罗伯逊易位携带者
核型分别为46
xx
t(4;5)(q
35
;q
31
);46
xx
t(6;13)(P
23
;q
22
);45
xx
t(13;13)(p
11
;q
11
);46
xx
t(2;13)(q
37
;q
22
).讨论了平衡染色体重排的断裂点
热点与染色体脆性部位三者之间的关系
分析了平衡易位是导致习惯性流产的染色体异常的一种主要形式
Abstract
Chromosome analysis were studied from 81 couples(162 cases)
who had two or more spontaneous abortions. Four cases of them showed chromosome abnarmalities(2.47%). All of them showed balanced translocation. The karyotypes are 46
xx
t(4; 5)(q35; q31)
46
xx
t(6; 13) (p23; q22); 45
xx
t(13; 13) (p11; q11); 46
xx
t(2; 13) (q37; q22). The results indicated that balanced chromosome rearrangement is the chief form of chromosome abnormalities and being carriers to cause abortion.