DETECTION OF CSF ANTIBODY LEVEL BY ELISA IN TUBERCULOUS MENINGITIS

Dept of Infectious Diseases: Jia Jie et al

doi:10.13406/j.cnki.cyxb.1987.04.002

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DETECTION OF CSF ANTIBODY LEVEL BY ELISA IN TUBERCULOUS MENINGITIS

更新时间：2024-01-17

- DETECTION OF CSF ANTIBODY LEVEL BY ELISA IN TUBERCULOUS MENINGITIS
- Journal of Chongqing Medical University Issue 4, Pages: 222-225(1987)
- 作者机构：
  
  重庆医科大学第一医院传染科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1987.04.002
  CLC：
- Published：1987，
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[1]贾杰,王其南,余登高.ELISA法检测结核性脑膜炎脑脊液中抗-BCG或抗-PPD水平[J].重庆医科大学学报,1987(04):222-225.

Dept of Infectious Diseases: Jia Jie et al. DETECTION OF CSF ANTIBODY LEVEL BY ELISA IN TUBERCULOUS MENINGITIS. [J]. Journal of Chongqing Medical University (4):222-225(1987)
[1]贾杰,王其南,余登高.ELISA法检测结核性脑膜炎脑脊液中抗-BCG或抗-PPD水平[J].重庆医科大学学报,1987(04):222-225. DOI： 10.13406/j.cnki.cyxb.1987.04.002.

Dept of Infectious Diseases: Jia Jie et al. DETECTION OF CSF ANTIBODY LEVEL BY ELISA IN TUBERCULOUS MENINGITIS. [J]. Journal of Chongqing Medical University (4):222-225(1987) DOI： 10.13406/j.cnki.cyxb.1987.04.002.

摘要

本研究用酶联免疫吸附试验（ELISA）对结核性、病毒性、隐球菌性脑膜炎及对照组脑脊液中牛型卡介苗结核杆菌（BCG）及PPD的IgG抗体进行了测定。结果显示抗-BCG与抗PPD水平呈正相关。研究发现

抗-BCG和抗-PPD水平在结核性脑膜炎组、非结核性脑膜炎组及对照组之间差异显著。如果以OD值0.16作为诊断结核性脑膜炎的标准

灵敏度达83.6%

特异性达97.6%

阳性预告值93.7%。所以本法对结核性脑膜炎早期诊断较为有用。

Abstract

Cerebrospinal fluid (CSF) from patients with tuberculous

viral and cryptococcus meningitis

as well.as from appropriate controls

were assayed for immunoglobulia G antibody activity to Mycobacterium bovis BCG and PPD by an enzyme-linked immunosorbent assay (ELISA). The results showed that the antibody activity against BCG and PPD increased pa-rallelly in tuberculous meningitis and this increase was significantly different from the non-tuberculous meningitis and control groups.If the OD 0.16 was arbitrarily set as the ELISA positive standard

then the sensitivity is 83.3%

the specificity is 97.6%

the predictive value is 93.7%. It is suggested that this test may be useful in the early diagnosis of tuberculous meningitis

关键词

结核性脑膜炎酶联免疫吸附试验BCGPPD

Keywords

tuberculous meningitis.ELISABCGPPD

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