ANALYSIS OF CHANGES IN SERUM PREALBUMIN, a1-ANTITRYPSIN, a1-ACID GLYCOPROTEIN AND HAPTOGLOBIN IN PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA

Department of Pathophysiology Duan Jihua Chen Sixiu Fan W eike Department of Medical Statistics Zhou Yanrong Zhong Xiaoni

doi:10.13406/j.cnki.cyxb.1987.03.005

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ANALYSIS OF CHANGES IN SERUM PREALBUMIN, a1-ANTITRYPSIN, a1-ACID GLYCOPROTEIN AND HAPTOGLOBIN IN PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA

更新时间：2024-01-17

- ANALYSIS OF CHANGES IN SERUM PREALBUMIN, a1-ANTITRYPSIN, a1-ACID GLYCOPROTEIN AND HAPTOGLOBIN IN PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA
- Journal of Chongqing Medical University Issue 3, Pages: 159-163(1987)
- 作者机构：
  
  1. 重庆医科大学病理生理教研室
  2. 重庆医科大学医学统计教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1987.03.005
  CLC：
- Published：1987，
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[1]段积华,陈思秀,范维珂,周燕荣,钟晓妮.原发性肝癌患者血清前白蛋白、α_1-抗胰蛋白酶、α_1-酸性糖蛋白及结合珠蛋白含量的分析[J].重庆医科大学学报,1987(03):159-163.

Department of Pathophysiology Duan Jihua Chen Sixiu Fan W eike Department of Medical Statistics Zhou Yanrong Zhong Xiaoni. ANALYSIS OF CHANGES IN SERUM PREALBUMIN, a1-ANTITRYPSIN, a1-ACID GLYCOPROTEIN AND HAPTOGLOBIN IN PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA. [J]. Journal of Chongqing Medical University (3):159-163(1987)
[1]段积华,陈思秀,范维珂,周燕荣,钟晓妮.原发性肝癌患者血清前白蛋白、α_1-抗胰蛋白酶、α_1-酸性糖蛋白及结合珠蛋白含量的分析[J].重庆医科大学学报,1987(03):159-163. DOI： 10.13406/j.cnki.cyxb.1987.03.005.

Department of Pathophysiology Duan Jihua Chen Sixiu Fan W eike Department of Medical Statistics Zhou Yanrong Zhong Xiaoni. ANALYSIS OF CHANGES IN SERUM PREALBUMIN, a1-ANTITRYPSIN, a1-ACID GLYCOPROTEIN AND HAPTOGLOBIN IN PATIENTS WITH PRIMARY HEPATOCELLULAR CARCINOMA. [J]. Journal of Chongqing Medical University (3):159-163(1987) DOI： 10.13406/j.cnki.cyxb.1987.03.005.

摘要

本文采用单向免疫扩散法对100例原发性肝癌、49例肝硬化、36例急性肝炎及60例正常人血清前白蛋白（PA）、α

-抗胰蛋白酶（α

-AT）、α

-酸性糖蛋白（α

-AG）及结合珠蛋白（HP）的含量进行了检测

结果表明原发性肝癌患者血清α

-AT及α

-AG非常显著地高于肝硬化、急性肝炎及正常人（P

0.001）;肝癌患者血清HP明显高于肝硬化及正常人（P

0.001及P

0.05）。33例AFP阴性肝癌患者血清α

-AT、α

-AG及HP均显著地高于良性肝病患者及正常人

这AFP阴性肝癌患者的鉴别诊断是非常有意义的。如将这三种糖蛋白再与AFP联合检测

则可大大地提高对原发性肝癌的诊断率。

Abstract

Serum prealbumin(PA)

a1-antitrypsin (a1-AT)

a1-acid glycoprotein (a1-AG) and hapto-globin (HP) were determined in 100 patients with primary hepatocellular carcinoma (HCC)

49 with cirrhosis

36 with acute hepatitis and 60 normal Wood donors by single radial iminuno-diffusion (SRID). Serum a1-AT and a1-AG levels were significantly elevated in patients with HCC as compared with those of cirrhosis

acute hepatitis or normal’ blood donors. Serum HP levels were significantly higher in patients with HCC than in with cirrhosis or normal blood donors. Serum a1-AT

a1-AG and HP in HCC patients with negative seruma-fetoprotein (AFP) were also significantly elevated. These results indicate that the difference in a1-AT

a1-AG and HP between AFP negative HCC patients and other liver diseases was very significant. If AFP and these three glycoproteins were simultaneously determined

the positive rate of HCC would be elevated.

关键词

原发性肝癌前白蛋白a1-抗胰蛋白酶a1-酸性糖蛋白结合珠蛋白单向免疫扩散法

Keywords

Primary hepatocellular carcinoma (HOC)Prealbumin (PA)di-Antitrypsin (a1~AT)a1-Acid glycoprotein (a1-AG)Haptoglobin (HP")Single radial immunodiffusion (SRID)

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