ANTIHYPERTENSIVE THERAPY AND INTRACELLULAR CATIONS

doi:10.13406/j.cnki.cyxb.1987.03.001

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ANTIHYPERTENSIVE THERAPY AND INTRACELLULAR CATIONS

更新时间：2024-01-17

- ANTIHYPERTENSIVE THERAPY AND INTRACELLULAR CATIONS
- Journal of Chongqing Medical University Issue 3, Pages: 139-142(1987)
- 作者机构：
  
  重庆医科大学第一医院内科心血管组
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1987.03.001
  CLC：
- Published：1987，
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[1]陈运贞,雷寒.降压治疗与细胞内离子的研究[J].重庆医科大学学报,1987(03):139-142.

ANTIHYPERTENSIVE THERAPY AND INTRACELLULAR CATIONS. [J]. Journal of Chongqing Medical University (3):139-142(1987)
[1]陈运贞,雷寒.降压治疗与细胞内离子的研究[J].重庆医科大学学报,1987(03):139-142. DOI： 10.13406/j.cnki.cyxb.1987.03.001.

ANTIHYPERTENSIVE THERAPY AND INTRACELLULAR CATIONS. [J]. Journal of Chongqing Medical University (3):139-142(1987) DOI： 10.13406/j.cnki.cyxb.1987.03.001.

摘要

本文报告了37例原发性高血压（EHT）用钙离子阻滞剂硝苯吡啶和血管紧张素转换酶抑制剂巯甲丙脯酸的降压效果与细胞内Na、K和Ca含量的变化。结果显示EHT病人的白细胞Na、Ca增高而K正常。降压治疗后两组均显示白细胞Na降低

P值分别为硝组<0.01

巯组<0.05。白细胞Ca则仅在硝组降低

P值<0.025。对细胞膜转运异常与高血压的关系、降压治疗后细胞离子变化的机制及钙通道阻滞剂在降压治疗中的地位分别作了讨论

Abstract

Thirty-seven essential hypertensive patients were treated with nifedipine and captopril. The effects of both drugs on high blood pressure and inteacellular cations were reported.A significant reduction in leucocyte Na concentration compared to the baseline were noted after therapy (P<0.01 in the group using nifedipine and P<0.05 in the other group). However

the intracellular Ca concentration was decreased signicantly only in the patients group using nifedipine

P<0.025.The relationship between the defect in ions transport crossing the celluar member and tesse-ntial hypertension

the mechanism of leucocyte cation reduced after therapy and the role of calcium antagonists in antihyperiensive therapy were discussed respectively

关键词

原发性高血压钠泵钙通道阻滞剂血管紧张素转换酶抑制剂

Keywords

essential hypertensionSodium . pumpCalcium antagonistAngiotensin converting enzyme inhibitor

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Related Institution

Department of Cardiovascular Medicine,Huaihe River Hospital of Henan University

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Department of Cardiology,College of Clinical Medicine,Chongqing Medical University

重庆医科大学临床学院心血管内科

Department of Cardiavascular Medicine,Zigong City Second People’s Hospital

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