THE EFFECT OF LITHIUM ADMINISTRATION TO CNS ON PAIN SENSITIVITY OF THE RATS

Department of Physiology. Sun Waqian Zhou Baohe

doi:10.13406/j.cnki.cyxb.1987.02.001

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THE EFFECT OF LITHIUM ADMINISTRATION TO CNS ON PAIN SENSITIVITY OF THE RATS

更新时间：2024-01-17

- THE EFFECT OF LITHIUM ADMINISTRATION TO CNS ON PAIN SENSITIVITY OF THE RATS
- Journal of Chongqing Medical University Issue 2, Pages: 75-79(1987)
- 作者机构：
  
  重庆医科大学生理教研室研究生
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1987.02.001
  CLC：
- Published：1987，
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[1]孙瓦签.中枢内直接施用锂盐对大鼠痛阈的影响[J].重庆医科大学学报,1987(02):75-79.

Department of Physiology. Sun Waqian Zhou Baohe. THE EFFECT OF LITHIUM ADMINISTRATION TO CNS ON PAIN SENSITIVITY OF THE RATS. [J]. Journal of Chongqing Medical University (2):75-79(1987)
[1]孙瓦签.中枢内直接施用锂盐对大鼠痛阈的影响[J].重庆医科大学学报,1987(02):75-79. DOI： 10.13406/j.cnki.cyxb.1987.02.001.

Department of Physiology. Sun Waqian Zhou Baohe. THE EFFECT OF LITHIUM ADMINISTRATION TO CNS ON PAIN SENSITIVITY OF THE RATS. [J]. Journal of Chongqing Medical University (2):75-79(1987) DOI： 10.13406/j.cnki.cyxb.1987.02.001.

摘要

本实验将氯化锂经慢性埋植导管注入大鼠双侧脑室或蛛网膜下腔内

显示有明显的镇痛作用

该作用能被纳络酮及酚妥拉明翻转;同样实验亦观察到大鼠端脑和间脑的去甲肾上腺素（NE）含量明显减少。结果初步表明:锂盐发挥镇痛作用的部位在中枢

其镇痛效果可能与内啡肽及NE的代谢改变有关并系通过鸦片受体及α-肾腺能受体而实现的

Abstract

The injection of lithium chloride into lateral ventricule of the brain (LV) or subarchnoid space of rats via chronically implanted cannula resulted in significantly analgesic effect that could be reversed by naloxone or phentolamine

but not by propranolol

lysergic acid diethylamine (LSD)and bicuculline.Rats were sacrificed by decapitation half an hr. after injection of Licl into LV for the determination of the content of norepinephrine (NE) in the brain. It was found that the content of NE of forebrain and diencephalon decreased by 17-27%

and 26-29% respectively.This result suggests that the analgesic effect of Li takes place in the central nervous system and it may be associated with the change of metabolism on enkaphalin and NE that produced analgesic effect via opiate receptors and alpha-adrenoceptors respectively

关键词

氯化锂慢性埋置导管侧脑室蛛网膜下腔纳络酮酚妥拉明心得安二乙基麦角酰胺荷包牡丹碱去甲肾上腺素

Keywords

Lithium chloride(LiCl)Cannulae implantationLVSSNaloxonePhentolaminePropranololLSDBicucullineNE

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