CHANGE OF BRAIN UPTAKE OF BLOOD GABA IN EXPERIMENTAL HEPATIC ENCEPHALOPATHY IN MICE

Department of Biochemistry Li Qian Wang Zhengtai

doi:10.13406/j.cnki.cyxb.1987.01.007

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CHANGE OF BRAIN UPTAKE OF BLOOD GABA IN EXPERIMENTAL HEPATIC ENCEPHALOPATHY IN MICE

更新时间：2024-01-17

- CHANGE OF BRAIN UPTAKE OF BLOOD GABA IN EXPERIMENTAL HEPATIC ENCEPHALOPATHY IN MICE
- Journal of Chongqing Medical University Issue 1, Pages: 13-17(1987)
- 作者机构：
  
  重庆医科大学生化教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1987.01.007
  CLC：
- Published：1987，
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[1]李倩,王征泰.实验性肝性脑病小鼠脑组织对血中GABA摄取的改变[J].重庆医科大学学报,1987(01):13-17.

Department of Biochemistry Li Qian Wang Zhengtai. CHANGE OF BRAIN UPTAKE OF BLOOD GABA IN EXPERIMENTAL HEPATIC ENCEPHALOPATHY IN MICE. [J]. Journal of Chongqing Medical University (1):13-17(1987)
[1]李倩,王征泰.实验性肝性脑病小鼠脑组织对血中GABA摄取的改变[J].重庆医科大学学报,1987(01):13-17. DOI： 10.13406/j.cnki.cyxb.1987.01.007.

Department of Biochemistry Li Qian Wang Zhengtai. CHANGE OF BRAIN UPTAKE OF BLOOD GABA IN EXPERIMENTAL HEPATIC ENCEPHALOPATHY IN MICE. [J]. Journal of Chongqing Medical University (1):13-17(1987) DOI： 10.13406/j.cnki.cyxb.1987.01.007.

摘要

Schafer在1982年提出的肝性脑病发病机理的GABA假说已在多方面得到实验支持。但肝损害时GABA进入脑组织是否增加至今未见直接报导。我们以尾静脉注射

H-GABA进行同位素示踪

并用醋酸纤维素薄膜电泳将

H-GABA与其代谢物分离。测定D-氨基半乳糖诱发肝性脑病的小鼠血和脑中放射性GABA（S/T%

B/T%）以及它在总非挥发性放射性物质中的构成比（S

H-GABA%

H-GABA%）。所得结果表明

实验性肝性脑病小鼠的S/T%

B/T%

H-GA-BA%及B

H-GABA%都明显高于正常小鼠

即肝性脑病时

脑从血中摄取GABA增加

推测是由于血脑屏障对GABA的通透性发生改变所致

Abstract

The GABA hypothesis for the pathogenesis of hepatic encephalopathy suggested bySchafer in 1982 had been supported by quite a lot of experimental data. However

up to now it is still unknown whether the brain uptake of blood GABA is increased or not in liver failure. For this purpose

we performed tracing experiments in mice with galactosami-ne-induced hepatic encephalopathy. After injection of 3H-GABA

the radiolabelled GABA in mice brain and serum were seperated from its metabolites by cellulose acetate electropho-resis and the redioactivities were determined(Serum/Total%; Brain/Total%). The ratio of 3H-GABA to total non-volatile radioactive compounds in serum and brain were also determined (Serum 3H-GABA%; Brain 3H-GABA%). Our results clearly indicated that Serum/ Total%

Brain/Total%

Serum 3H-GABAfo

and Brain 3H-GABA% of mice wisth gala-ctosamine-induced hepatic encephalopathy were significantly higher than that of the normal. It was concluded that the brain uptake of GABA from blood was increased in mice with experimental hepatic encephalopathy and it may be the result of the change of permeability of blood brain barrier to GABA in liver failure

关键词

肝性脑病GABA血脑屏障

Keywords

hepatic encephalopathyGABABlood-brain barrier

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