COMPARTIYE EFFICACY OF LEVOPRAZIQUANTEL AND PRAZIQUANTEL IN THE TREATMENT OF SCHISTOSOMA JAPONICUM INFECTION

doi:10.13406/j.cnki.cyxb.1987.01.005

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COMPARTIYE EFFICACY OF LEVOPRAZIQUANTEL AND PRAZIQUANTEL IN THE TREATMENT OF SCHISTOSOMA JAPONICUM INFECTION

更新时间：2024-01-17

- COMPARTIYE EFFICACY OF LEVOPRAZIQUANTEL AND PRAZIQUANTEL IN THE TREATMENT OF SCHISTOSOMA JAPONICUM INFECTION
- Journal of Chongqing Medical University Issue 1, Pages: 9-12(1987)
- 作者机构：
  
  1. 重庆医科大学血吸虫病研究室
  2. 四川省寄生虫病防治研究所
  3. 四川省芦山县血防站
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1987.01.005
  CLC：
- Published：1987，
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[1]王小根,刘约翰,严桑和,陈伯毅,钱明心,郑行萍,王其南,金介梅,张桂盛,龙劲松,王亭,黄涛,徐光俊.左旋吡喹酮与吡喹酮治疗慢性日本血吸虫病对比观察[J].重庆医科大学学报,1987(01):9-12.

COMPARTIYE EFFICACY OF LEVOPRAZIQUANTEL AND PRAZIQUANTEL IN THE TREATMENT OF SCHISTOSOMA JAPONICUM INFECTION. [J]. Journal of Chongqing Medical University (1):9-12(1987)
[1]王小根,刘约翰,严桑和,陈伯毅,钱明心,郑行萍,王其南,金介梅,张桂盛,龙劲松,王亭,黄涛,徐光俊.左旋吡喹酮与吡喹酮治疗慢性日本血吸虫病对比观察[J].重庆医科大学学报,1987(01):9-12. DOI： 10.13406/j.cnki.cyxb.1987.01.005.

COMPARTIYE EFFICACY OF LEVOPRAZIQUANTEL AND PRAZIQUANTEL IN THE TREATMENT OF SCHISTOSOMA JAPONICUM INFECTION. [J]. Journal of Chongqing Medical University (1):9-12(1987) DOI： 10.13406/j.cnki.cyxb.1987.01.005.

摘要

左旋吡喹酮与吡喹酮治疗血吸虫病患者189例和75例。均按30mg/kg的剂量

顿服

治后3个月与6个月粪孵阴转率分别为84.3%、86.5%与71.6%、72.9%;累积阴转率分别为73.5%与60.2%。二组的疗效比较有非常显著差异（p<0.01）。左旋吡喹酮组的无反应率（70.4%）与吡喹酮组（69.1％）比较则无差异（p>0.05）。该两药毒副反应均轻而短暂

无需特殊处理

自行缓解。治疗前与治后肝、肾功能

心电图和血、尿常规检查均无明显变化。临床研究结果证明左旋吡喹酮单剂疗法的疗效优于吡喹酮。我们认为左旋吡喹酮可用于血吸虫病流行区大规模普治

Abstract

A prospective randomized study to compare the efficacy of levopraziquantel (189 cases) and praziquantel (75 cases) in the treatment of Schistosoma japonicum infection was reported. All patients were positive by stool hatching test before treatment and were treated with the same single dose of 30 mg/kg. The stool negative conversion rates 3 and 6 months after treatment in levopraziquantel group were 84.3% and 86.5% respectively

while that of praziquantel group were 71.6% and 72.9% respectively (p<0. 01). The side reactions of both groups were mild and transient. Liver and renal functions test

eletrocardiograms

blood and urine examinations showed no remarkable changes. Evdently levopraziquantel was superior to praziquantel in therapeutic effect. It mey be used for mass treatment in schistosomiasis endemic areas

关键词

左旋吡喹酮吡喹酮粪孵日本血吸虫病

Keywords

Levopraziquantelpraziquantelstool hatching testschistosomiasis japonicum

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A new and efficient method for the synthesis of praziquantel,an antischistosomiasis drug

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Department of Pharmacochemistry,College of Pharmacy,Chongqing Medical University, Chongqing Engineering Research Center for Drug

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