SERIAL OBSERVATION ON THE RELATIONSHIP BETWEEN EXPERIMENTAL MYOCARDIAL INFARCT SIZE AND LEFT VENTRICULAR FUNCTION IN RATS

Department of Pathophysiology Du Xiaojun

doi:10.13406/j.cnki.cyxb.1986.03.010

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SERIAL OBSERVATION ON THE RELATIONSHIP BETWEEN EXPERIMENTAL MYOCARDIAL INFARCT SIZE AND LEFT VENTRICULAR FUNCTION IN RATS

更新时间：2024-01-17

- SERIAL OBSERVATION ON THE RELATIONSHIP BETWEEN EXPERIMENTAL MYOCARDIAL INFARCT SIZE AND LEFT VENTRICULAR FUNCTION IN RATS
- Journal of Chongqing Medical University Issue 3, Pages: 178-181(1986)
- 作者机构：
  
  重庆医科大学病理生理教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1986.03.010
  CLC：
- Published：1986，
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[1]杜晓军.实验性心肌梗塞范围与左心室功能之间关系的动态观察[J].重庆医科大学学报,1986(03):178-181.

Department of Pathophysiology Du Xiaojun. SERIAL OBSERVATION ON THE RELATIONSHIP BETWEEN EXPERIMENTAL MYOCARDIAL INFARCT SIZE AND LEFT VENTRICULAR FUNCTION IN RATS. [J]. Journal of Chongqing Medical University (3):178-181(1986)
[1]杜晓军.实验性心肌梗塞范围与左心室功能之间关系的动态观察[J].重庆医科大学学报,1986(03):178-181. DOI： 10.13406/j.cnki.cyxb.1986.03.010.

Department of Pathophysiology Du Xiaojun. SERIAL OBSERVATION ON THE RELATIONSHIP BETWEEN EXPERIMENTAL MYOCARDIAL INFARCT SIZE AND LEFT VENTRICULAR FUNCTION IN RATS. [J]. Journal of Chongqing Medical University (3):178-181(1986) DOI： 10.13406/j.cnki.cyxb.1986.03.010.

摘要

心肌梗塞（MI）后梗死范围（IS）与心功能的相关关系有无时相差异尚不清楚。本文用开胸结扎左冠状动脉的方法造成大鼠左室MI

分别于术后第3、9、21和35天测定多项心动能指标及IS（占左室10～65％不等）

比较各组的IS与心功能指标的相关程度。实验结果提示

MI急性期的相关程度有差于其余时期的趋势

不同IS的心室功能具有不同的演变规律是造成此种差异的机理

Abstract

To assess the phase-character of the relationship between myocardial infarct size (IS) and left yentricular function (LVF)

myocardial infarction (MI) of left ventricle was produced in rats by coronary ligation. The indices of LVF and IS were measured on 3 (n=24)

9(n=22)

21 (n=25)

and 35-day groups (n=23) respectively after the operation

and their correlations were compaired among the four groups. Significant correlations between IS (ranging from 10 to 65% of the left ventricle) and functional indices were found in all groups

denoting IS to be the most important determinant on LVF in the different phases of MI. In the acute phase (3-day group)

however

this relationship was not as good as that in the other phases

which might be explained by the diverse revolving-types of cardiac function in ventricles with a spectrum of IS after MI

or by the time-dependent effects of other influencial factors on LVF

关键词

心肌梗塞心肌梗死范围心功能心输出量大鼠

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