DISPOSITION OF ~3H-PIPERAZINE FERULATE IN RATS

doi:10.13406/j.cnki.cyxb.1986.03.003

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DISPOSITION OF ~3H-PIPERAZINE FERULATE IN RATS

更新时间：2024-01-17

- DISPOSITION OF ~3H-PIPERAZINE FERULATE IN RATS
- Journal of Chongqing Medical University Issue 3, Pages: 154-157(1986)
- 作者机构：
  
  1. 重庆医科大学第一医院临床药理研究室
  2. 重庆医科大学基础医学部药理教研室
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.1986.03.003
  CLC：
- Published：1986，
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[1]朱治本,王捷,左六一,周蓓,刘文清.~3H一阿魏酸哌嗪在大鼠的体内过程[J].重庆医科大学学报,1986(03):154-157.

DISPOSITION OF ~3H-PIPERAZINE FERULATE IN RATS. [J]. Journal of Chongqing Medical University (3):154-157(1986)
[1]朱治本,王捷,左六一,周蓓,刘文清.~3H一阿魏酸哌嗪在大鼠的体内过程[J].重庆医科大学学报,1986(03):154-157. DOI： 10.13406/j.cnki.cyxb.1986.03.003.

DISPOSITION OF ~3H-PIPERAZINE FERULATE IN RATS. [J]. Journal of Chongqing Medical University (3):154-157(1986) DOI： 10.13406/j.cnki.cyxb.1986.03.003.

摘要

本文用大鼠研究了

H-阿魏酸哌嗪的体内过程及其药物动力学特点。胃肠分段结扎后局部给药2h内的吸收量小肠为58.2%

胃为35.4%。仅有少量（

1%）由小肠粘膜分泌。静注、肌注及口服的药-时曲线符合开放型二室模型。静注后12h由胆汁排出33.8%

而粪中仅排出11.4%

故通过肝肠循环重吸收的比例较高

Abstract

The disposition and pharmacokinetic characteristics of 3H-piperzine ferulate (3H-PF) were studied in present paper.3H-PF absorbed during 2h were 35.4% in stomach and 58.2% in intestine.The blood concentration-time curves obtained from 3H-PF given iv

im and po were adquat-ely fitted by an open two-compartment model. The t=6.8(iv)

19.2(im) and 29.0(po) min; t=47.2min(iv)

1.97(im) and 5.5h(po); Tm=19(im) and 30(po)min. The protein binding% = 38.5(iv) and 31.3(po).When injected iv

the drug was found in higher concentration in liver

kidneys

lungs and blood. After oral administration

higher contents were also found in stomach

intestion and fats in addition to above organs and tissues. The drug could penetrate placenta barrier and distribute into amniotic fluid

placenta and foetus.The excretion rates in 24h were 29.0g6(iv)

18.4%(po)in urine and 14.?9fe(iv)

7.9%(po) in feaces. 33.8% of the iv dose was excreted in the bile during a period of 12h

and there was only 11.4% presented in the feaces. The result indicated that a higher proportion is reabsorbed through hepato-intestnial circulation

关键词

3H—阿魏酸哌嗪体内过程药物动力学大鼠

Keywords

3H-piperazine ferulatedispositionPharmacokineticsrat

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Related Institution

Department of Urology,the Children’s Hospital,Chongqing Medical University,Ministry of Education Key Laboratory of Child Development and Disorders,Key Laboratory of Pediatrics in Chongqing,Chongqing International Science and Technology Cooperation Center for Child Development and Disorders

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