Advances in mesenchymal stem cell migration for treating spinal cord injury

Guo Dong; Chang Sue; He Xijing; Li Jiaxi; Yang Yubing

doi:10.13406/j.cnki.cyxb.003105

您当前的位置：

首页 >

文章列表页 >

Advances in mesenchymal stem cell migration for treating spinal cord injury

Literature review | 更新时间：2022-11-09

- Advances in mesenchymal stem cell migration for treating spinal cord injury
- Journal of Shanxi Agricultural Sciences Vol. 47, Issue 10, Pages: 1133-1138(2022)
- 作者机构：
  
  西安交通大学第二附属医院骨二科，西安　710004
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.003105
  CLC： R651
- Published：28 October 2022，
  
  Received：21 March 2022，
扫描看全文
Guo Dong, Chang Sue, He Xijing, et al. Advances in mesenchymal stem cell migration for treating spinal cord injury. [J]. Journal of Shanxi Agricultural Sciences 47(10):1133-1138(2022)
DOI：

Guo Dong, Chang Sue, He Xijing, et al. Advances in mesenchymal stem cell migration for treating spinal cord injury. [J]. Journal of Shanxi Agricultural Sciences 47(10):1133-1138(2022) DOI： 10.13406/j.cnki.cyxb.003105.

摘要

脊髓损伤（spinal cord injury，SCI）通常会导致严重的神经功能障碍。间充质干细胞（mesenchymal stem cell，MSC）是治疗SCI最有前途的干细胞类型之一。MSC移植后的低迁移效率、低存活率和低分化率严重限制了MSC移植在临床上的应用。此外，大量研究显示不论是静脉注射还是脊髓内注射，很少有细胞发生定向迁移和整合。近年研究显示，MSC的定向迁移受细胞因子、基因转录表达和组织工程影响。本文从细胞因子、基因表达调控及组织工程3个方面对MSC迁移的作用进行总结，同时归纳近年通过促进MSC迁移治疗SCI策略的研究进展，为进一步提高治疗SCI的效果、实现精准医疗提供思路。

Abstract

Spinal cord injury（SCI） usually leads to severe neurological dysfunction. Mesenchymal stem cell（MSC） are considered as one of the most promising stem cell types to treat SCI. However，the low migration efficiency，low survival rate and low differentiation rate after MSC transplantation seriously limit the clinical application of MSC transplantation. In addition，numerous studies have shown that targeted migration and integration occurs to very little cells either by intravenous or intraspinal injection. Recent studies have shown that the directional migration of MSC is influenced by cytokine induction，transcriptional gene expression，and tissue engineering. In this review，we summarize the role of MSC migration in terms of cytokines，gene expression regulation，tissue engineering，and the progress of recent research on strategies to treat SCI by promoting MSC migration. It will provide ideas to further improve the effectiveness of treatment of SCI and realize precision medicine.

关键词

脊髓损伤迁移间充质干细胞

Keywords

spinal cord injurymigrationmesenchymal stem cell

references

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research progress of chondroitin sulfate proteoglycans in spinal cord injury

Prediction of key genes and study of related pathological mechanisms in mice with spinal cord injury by RNA sequencing combined with TMT proteomics technology

MCU regulates metastasis of oral squamous cell carcinoma cells by maintaining mitochondrial calcium homeostasis through LETM1

Current situation and prospect of mesenchymal stem cells in the treatment of renal fibrosis

Clinical and biological significance of MYH9 in human hepatocellular carcinoma and its role in cell migration and invasion

Related Author

Liu Yong

Shi Yongqiang

Mao Peng

Zhang Haihong

Yang Zhuxin

Tang Chenglin

Zhao Hongdi

Li Mingjiao

Related Institution

Department of Orthopedics，The Second Hospital of Lanzhou University/Key Laboratory of Bone and Joint Diseases of Gansu Province

College of Traditional Chinese Medicine,Chongqing Medical University

Department of Traditional Chinese Medicine,Affiliated Hospital of Chifeng University

Department of Stomatology，Tangshan Vocational and Technical College

Department of Orthodontic Prosthodontics，North China University of Science and Technology Affiliated Hospital

⁰