Clinical diagnostic value of metastasis-associated lung adenocarcinoma transcript 1 in peripheral blood of patients with oral squamous cell carcinoma

Chen Rui

doi:10.13406/j.cnki.cyxb.002957

您当前的位置：

首页 >

文章列表页 >

Clinical diagnostic value of metastasis-associated lung adenocarcinoma transcript 1 in peripheral blood of patients with oral squamous cell carcinoma

更新时间：2024-01-09

- Clinical diagnostic value of metastasis-associated lung adenocarcinoma transcript 1 in peripheral blood of patients with oral squamous cell carcinoma
- Journal of Chongqing Medical University Vol. 46, Issue 12, Pages: 1507-1510(2021)
- 作者机构：
  
  重庆医科大学附属第一医院口腔颌面外科,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002957
  CLC： R782
- Published：2021，
扫描看全文
Chen Rui. Clinical diagnostic value of metastasis-associated lung adenocarcinoma transcript 1 in peripheral blood of patients with oral squamous cell carcinoma. [J]. Journal of Chongqing Medical University 46(12):1507-1510(2021)
DOI：

Chen Rui. Clinical diagnostic value of metastasis-associated lung adenocarcinoma transcript 1 in peripheral blood of patients with oral squamous cell carcinoma. [J]. Journal of Chongqing Medical University 46(12):1507-1510(2021) DOI： 10.13406/j.cnki.cyxb.002957.

摘要

目的：探讨外周血中肺腺癌转移相关转录本1（metastasis-associated lung adenocarcinoma transcript 1，MALAT1）对口腔鳞状细胞癌（oral squamous cell carcinoma，OSCC）的临床诊断价值。方法：采用荧光定量RT-qPCR方法检测OSCC患者术前外周血样本及配对术后癌组织中MALAT1的表达。结果： MALAT1在OSCC患者外周血中的平均表达水平明显高于健康志愿者（1.845±0.142 vs.0.642±0.090，P<0.001）；MALAT1在外周血中的表达水平与配对癌组织成正相关，相关系数为0.783（P<0.001）；MALAT1在外周血中的表达水平与肿瘤TNM分期（P=0.001）及细胞分化程度相关（P=0.010）；MALAT1对OSCC诊断的ROC曲线下面积为0.892，当截断值为0.788时，其诊断灵敏度为85%，特异度为81%。结论： MALAT1对OSCC具有较好的临床诊断价值，有望成为OSCC疾病诊断、预后判断的血清分子标志物。

Abstract

Objective: To investigate the clinical diagnostic value of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the peripheral blood of patients with oral squamous cell carcinoma (OSCC). Methods: Fluoresence quantitative RT-qPCR was used to detect the expression of MALAT1 in the preoperative peripheral blood samples and paired postoperative tumor tissues of patients with OSCC. Results: The mean expression level of MALAT1 in peripheral blood of patients with OSCC was significantly higher than that of healthy volunteers (1.845±0.142 vs.0.642±0.090

P<0.001). The expression level of MALAT1 in peripheral blood was positively correlated with the paired tumor tissues with a correlation coefficient of 0.783 (P<0.001). The expression level of MALAT1 in peripheral blood was correlated with tumor TNM stage (P=0.001) and cell differentiation (P=0.010). The area under the ROC curve of MALAT1 for the diagnosis of OSCC was 0.892.When the cutoff value was 0.788

the diagnostic sensitivity and specificity of MALAT1 were 85%and 81%respectively. Conclusion: MALAT1 has potential clinical value of diagnosing OSCC

and is expected to be a serum molecular marker for the diagnosis and prognosis of OSCC.

关键词

口腔鳞状细胞癌肺腺癌转移相关转录本1外周血诊断价值

Keywords

oral squamous cell carcinomametastasis-associated lung adenocarcinoma transcript 1peripheral blooddiagnostic value

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

MCU regulates metastasis of oral squamous cell carcinoma cells by maintaining mitochondrial calcium homeostasis through LETM1

Development and validation of an insulin sensitivity score in female with polycystic ovary syndrome

Application of super-selective intra-arterial infusion chemotherapy in the neoadjuvant chemotherapy for oral squamous cell carcinoma

Value of computed tomography venography/angiography of both lower extremities via both great saphenous veins in the imaging diagnosis of iliac vein compression syndrome

Advance of colorectal cancer’ molecular diagnostic biomarkers-circulating free miRs

Related Author

Wu Ran

Liu Hui

Zheng Shen

Zuo Weiwen

Bi Lei

Chen Hui

Zhang Chunguang

Xu Xiaoliang

Related Institution

Department of Stomatology，North China University of Science and Technology Affiliated Hospital

Department of Orthodontic Prosthodontics，North China University of Science and Technology Affiliated Hospital

Department of Stomatology，Tangshan Vocational and Technical College

Department of Stomatology，The Second Hospital of Tangshan

Department of Endocrinology,The First Affiliated Hospital of Chongqing Medical University

⁰