A clinical study of 227cases of pregnancy complicated with connective tissue diseases treated by hydroxychloroquine

Zeng Hui; He Fan; Dong Xiaojing; Tang Lin; Zhao Wenlong; Yang Zhu; Hu Lina

doi:10.13406/j.cnki.cyxb.002937

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A clinical study of 227cases of pregnancy complicated with connective tissue diseases treated by hydroxychloroquine

Clinical research | 更新时间：2022-11-09

- A clinical study of 227cases of pregnancy complicated with connective tissue diseases treated by hydroxychloroquine
- Journal of Shanxi Agricultural Sciences Vol. 47, Issue 10, Pages: 1210-1214(2022)
- 作者机构：
  
  重庆医科大学附属第二医院妇产科、重庆医科大学医学数据研究院，重庆　40010
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002937
  CLC： R71
- Published：28 October 2022，
  
  Received：15 March 2021，
扫描看全文
Zeng Hui, He Fan, Dong Xiaojing, et al. A clinical study of 227cases of pregnancy complicated with connective tissue diseases treated by hydroxychloroquine. [J]. Journal of Shanxi Agricultural Sciences 47(10):1210-1214(2022)
DOI：

Zeng Hui, He Fan, Dong Xiaojing, et al. A clinical study of 227cases of pregnancy complicated with connective tissue diseases treated by hydroxychloroquine. [J]. Journal of Shanxi Agricultural Sciences 47(10):1210-1214(2022) DOI： 10.13406/j.cnki.cyxb.002937.

摘要

目的：

研究羟氯喹（hydroxychloroquine，HCQ）治疗能否改善结缔组织疾病（connective tissue disease，CTD）患者的妊娠结局。

方法：

本研究为多中心回顾性队列研究，收集重庆医科大学医渡云数据库中（纳入6家医院）近10年（2010年1月1日至2020年10月30日）妊娠合并CTD的病例。最终纳入227例CTD患者，根据这些患者在妊娠前6个月或妊娠期间是否开始HCQ治疗分为2组：HCQ治疗组（108例）和HCQ对照组（119例）。

结果：

HCQ治疗组发生妊娠期高血压（5.0% vs.17.6%，

=0.003）、早产（19.3% vs. 25.0%，

=0.303）和低出生体质量儿（20.0% vs. 45.0%，

0.001）的风险较对照组明显降低。进一步多元回归分析发现，HCQ是妊娠期高血压（

=0.31，95%CI=0.10~0.93，

=0.037）、早产（

=0.28，95%CI=0.10~0.79，

=0.016）和低出生体质量儿（

=0.31，95%CI=0.13~0.72，

=0.006）的独立保护因素。

结论：

HCQ能有效改善CTD患者的妊娠结局，尤其是降低妊娠期高血压、早产和低出生体质量儿发生的风险。

Abstract

Objective:

To examine the effects of hydroxychloroquine（HCQ） treatment on pregnancy outcomes in women with connective tissue disease（CTD）.

Methods:

We conducted a retrospective cohort study of pregnant women with CTD in 6 hospitals in recent 10 years（from January 1，2010 to October 30，2020），taking the medical records of Chongqing Medical University Medical Data Scinece Acadmy. A total of 227 patients were included in the study，and classified into two groups according to whether they started HCQ treatment during or six months prior to pregnancy，HCQ treatment group（

=108） and control group（

=119）.

Results:

Compared with the patients in the HCQ treatment group，we found that patients in the control group were more likely to have gestational hypertension（5.0% vs. 17.6%，

=0.003），preterm birth（19.3% vs. 25.0%，

=0.303），and low birth weight infant（20.0% vs. 45.0%，

0.001）. Multivariate analysis showed that HCQ treatment was associated with an exceedingly lower risk of gestational hypertension（

=0.31，95%CI=0.10-0.93，

=0.037），preterm birth（

=0.28，95%CI=0.10-0.79，

=0.016） and low birth weight infant（

=0.31，95%CI=0.13-0.72，

=0.006） after controlling for important confounding variables.

Conclusion:

Our study proved that HCQ treatment can significantly improve the pregnancy outcomes of patients with CTD，especially reduce the risk of gestational hypertension，preterm birth and low birth weight infant.

关键词

羟氯喹结缔组织疾病妊娠期高血压早产低出生体质量儿

Keywords

hydroxychloroquineconnective tissue diseasegestational hypertensionpreterm birthlow birth weight infant

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