Advances in the study of hippocampal subregion in Alzheimer's disease

Shuyue Lü; Wenyue Sun; Fan Wu; Qing Zhao

doi:10.13406/j.cnki.cyxb.002923

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Advances in the study of hippocampal subregion in Alzheimer's disease

Correlation analysis of cognitive impairment and central biomarkers | 更新时间：2022-06-24

- Advances in the study of hippocampal subregion in Alzheimer's disease
- Journal of Shanxi Agricultural Sciences Vol. 46, Issue 11, Pages: 1391-1394(2021)
- 作者机构：
  
  吉林大学中日联谊医院南湖神经内科、吉林省记忆与认知障碍疾病工程实验室，长春　130000
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002923
  CLC： R741
- Published：28 November 2021，
  
  Received：31 July 2021，
扫描看全文
Shuyue Lü, Wenyue Sun, Fan Wu, et al. Advances in the study of hippocampal subregion in Alzheimer's disease. [J]. Journal of Shanxi Agricultural Sciences 46(11):1391-1394(2021)
DOI：

Shuyue Lü, Wenyue Sun, Fan Wu, et al. Advances in the study of hippocampal subregion in Alzheimer's disease. [J]. Journal of Shanxi Agricultural Sciences 46(11):1391-1394(2021) DOI： 10.13406/j.cnki.cyxb.002923.

摘要

阿尔茨海默病（Alzheimer's disease，AD）是一种进行性的神经系统退行性疾病。海马是AD发病过程中最早且特异性较高的一种标志物，分为CA1~4亚区。海马亚区涉及情景记忆、社会记忆、联想记忆的处理，其改变与衰老、Aβ沉积、tau蛋白过度磷酸化、缺血等影响因素相关。研究海马亚区与AD的相关性，对AD的早期识别及诊断具有重要临床意义，可能为AD的治疗提供新的思路。

Abstract

Alzheimer's disease (AD) is a progressive neurodegenerative disease. The hippocampus is the earliest and highly specific marker in the pathogenesis of AD

which can be divided into CA1-4 subregions. The hippocampal subregion is involved in the processing of episodic memory

social memory and associative memory

and is associated with aging

Aβ deposition

hyperphosphorylation of tau protein

ischemia and other influencing factors. The study of the changes in the hippocampal subregion in AD is of great clinical significance for the early identification and diagnosis of AD

and may provide new ideas for the treatment of AD.

关键词

阿尔茨海默病海马海马亚区认知功能

Keywords

Alzheimer's diseasehippocampushippocampal subregioncognitive function

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