Advances in neuroimaging studies about default network subsystem mediating episodic memory dysfunction in AD spectrum patients

Weina Yao; Feng Bai

doi:10.13406/j.cnki.cyxb.002920

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Advances in neuroimaging studies about default network subsystem mediating episodic memory dysfunction in AD spectrum patients

Correlation analysis of cognitive impairment and central biomarkers | 更新时间：2022-06-24

- Advances in neuroimaging studies about default network subsystem mediating episodic memory dysfunction in AD spectrum patients
- Journal of Shanxi Agricultural Sciences Vol. 46, Issue 11, Pages: 1395-1398(2021)
- 作者机构：
  
  1.南京中医药大学中西医结合鼓楼临床医学院，南京　210008
  2.南京大学医学院附属鼓楼医院神经内科，南京　210008
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002920
  CLC： R741.02
- Published：28 November 2021，
  
  Received：01 August 2021，
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Weina Yao, Feng Bai. Advances in neuroimaging studies about default network subsystem mediating episodic memory dysfunction in AD spectrum patients. [J]. Journal of Shanxi Agricultural Sciences 46(11):1395-1398(2021)
DOI：

Weina Yao, Feng Bai. Advances in neuroimaging studies about default network subsystem mediating episodic memory dysfunction in AD spectrum patients. [J]. Journal of Shanxi Agricultural Sciences 46(11):1395-1398(2021) DOI： 10.13406/j.cnki.cyxb.002920.

摘要

阿尔茨海默病（Alzheimer's disease，AD）及其风险人群轻度认知障碍（mild cognitive impairment，MCI）是最常见的认知功能障碍，其核心损害表现为情节记忆功能障碍。默认网络（default network，DMN）由核心子系统（Core）、背内侧前额叶子系统（dorsal medial prefrontal cortex，DMPFC）和内侧颞叶子系统（medial temporal lobe，MTL）组成，3个子系统相互协作共同维持情节记忆功能的稳态。然而，AD谱系患者中上述子系统的相互作用模式尚不明确。本文将系统回顾该领域的研究进展，揭示AD谱系患者特有的损害特征，这将为AD谱系疾病早期筛查、进展监控、疗效评估以及相关认知障碍疾病的鉴别诊断提供重要的思路。

Abstract

Alzheimer's disease (AD) and its risk population of mild cognitive impairment (MCI) are the most common cognitive impairments

whose core impairment is episodic memory dysfunction. The default network (DMN) is composed of the core subsystem (Core)

the dorsal medial prefrontal cortex (DMPFC) subsystem and the medial temporal lobe (MTL) subsystem. The three subsystems cooperate with each other to maintain the steady state of episodic memory function. However

the patterns of interaction of these subsystems in AD spectrum patients are not clear yet. In this study

we will systematically review the advances of neuroimaging studies in this field

and the specific impairment characteristics of AD spectrum patients

which will provide important ideas for early screening

progression monitoring

efficacy evaluation and differential diagnosis of AD spectrum diseases.

关键词

情节记忆功能障碍默认网络子系统稳态神经影像

Keywords

episodic memory dysfunctiondefault networksubsystemsteady stateneuroimaging

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