Research progress of cognition, sleep and plasma biomarkers in patients with cerebral small vessel disease

Xiaohan Chen; Baofeng Gong; Jianjian Chu; Peng Li; Jin Xu; Genru Li; Wenbin Cheng; Wenbo Ji; Bin He; Jianhua Zhuang; You Yin

doi:10.13406/j.cnki.cyxb.002915

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Research progress of cognition, sleep and plasma biomarkers in patients with cerebral small vessel disease

Correlation analysis of cognitive impairment and peripheral biomarkers | 更新时间：2022-06-24

- Research progress of cognition, sleep and plasma biomarkers in patients with cerebral small vessel disease
- Journal of Shanxi Agricultural Sciences Vol. 46, Issue 11, Pages: 1342-1347(2021)
- 作者机构：
  
  海军军医大学第二附属医院神经内科，上海　200003
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002915
  CLC： R320.54
- Published：28 November 2021，
  
  Received：03 July 2021，
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Xiaohan Chen, Baofeng Gong, Jianjian Chu, et al. Research progress of cognition, sleep and plasma biomarkers in patients with cerebral small vessel disease. [J]. Journal of Shanxi Agricultural Sciences 46(11):1342-1347(2021)
DOI：

Xiaohan Chen, Baofeng Gong, Jianjian Chu, et al. Research progress of cognition, sleep and plasma biomarkers in patients with cerebral small vessel disease. [J]. Journal of Shanxi Agricultural Sciences 46(11):1342-1347(2021) DOI： 10.13406/j.cnki.cyxb.002915.

摘要

近年来随着神经影像技术的提高与普及，越来越多的脑小血管病被正确识别，脑小血管病在老年人群中已经成为一类常见病。脑小血管病能够引起一系列威胁患者健康的问题，尤其是认知功能损害，但由于疾病早期症状不突出，影像学检查滞后等原因，目前临床仍然缺乏有效的手段尽早识别此类疾病。本文阐述了脑小血管病的影像分型以及其特征性认知功能改变，探讨睡眠和血浆生物标志物与脑小血管病之间的关系，为临床早期鉴别诊断和个体化治疗提供有力依据。

Abstract

In recent years

with the improvement and popularization of neuroimaging technology

more and more cases of cerebral small vessel disease (CSVD) have been correctly identified

and it has become a common disease among the elderly. CSVD can cause a series of problems threatening patients'health

especially cognitive impairment. However

due to the lack of prominent early symptoms and lagging imaging examination

there is still a lack of effective means to identify such diseases as soon as possible. This paper expounds the imaging classification of CSVD and its characteristic cognitive function changes

and discusses its relationship between sleep and plasma biomarkers

so as to provide a strong basis for early clinical differential diagnosis and individualized treatment.

关键词

脑小血管病影像分型认知功能睡眠血浆生物标志物

Keywords

cerebral small vessel diseaseimaging classificationcognitive functionsleepplasma biomarkers

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