Research progress of gut microbiota and its metabolites as diagnostic biomarkers of Alzheimer's disease

Lizhen Cheng; Ya Miao

doi:10.13406/j.cnki.cyxb.002909

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Research progress of gut microbiota and its metabolites as diagnostic biomarkers of Alzheimer's disease

Correlation analysis of cognitive impairment and peripheral biomarkers | 更新时间：2022-06-24

- Research progress of gut microbiota and its metabolites as diagnostic biomarkers of Alzheimer's disease
- Journal of Shanxi Agricultural Sciences Vol. 46, Issue 11, Pages: 1352-1354(2021)
- 作者机构：
  
  上海交通大学附属第六人民医院老年病科，上海　200235
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002909
  CLC： R749.16
- Published：28 November 2021，
  
  Received：05 July 2021，
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Lizhen Cheng, Ya Miao. Research progress of gut microbiota and its metabolites as diagnostic biomarkers of Alzheimer's disease. [J]. Journal of Shanxi Agricultural Sciences 46(11):1352-1354(2021)
DOI：

Lizhen Cheng, Ya Miao. Research progress of gut microbiota and its metabolites as diagnostic biomarkers of Alzheimer's disease. [J]. Journal of Shanxi Agricultural Sciences 46(11):1352-1354(2021) DOI： 10.13406/j.cnki.cyxb.002909.

摘要

阿尔茨海默病（Alzheimer's disease，AD）是老年期痴呆最常见的一种类型，随着“脑-肠轴”理论的提出，越来越多的研究证实AD的发生发展与肠道菌群构成及其代谢产物的改变密切相关。本文就近年肠道菌群及其代谢产物在AD领域的研究进行综述和讨论，以此为着眼点，阐述以粪便为标本的肠道菌群及其代谢产物检查作为AD诊断生物标志物的应用前景。

Abstract

Alzheimer's disease (AD) is the main cause of senile dementia. With the proposal of the "brain-gut axis" theory

more and more studies have confirmed the occurrence and development of AD are closely related to the change of gut microbiota and its metabolites. This article reviews and discusses the changes of fecal gut microbiota and its metabolites occurred in AD. Besides

the application prospects of fecal gut microbiota and its metabolites as AD diagnostic biomarkers are described.

关键词

阿尔茨海默病肠道菌群生物标志物

Keywords

Alzheimer's diseasegut microbiotabiomarkers

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