Quantitative electroencephalogram analysis in patients with semantic dementia

Xiangfei Zhang; Pei Rong; Chunlei Hou; Wenjing Zheng; Zhi Zhou; Xiaoxuan Li; Renbin Wang; Xudong Li

doi:10.13406/j.cnki.cyxb.002906

您当前的位置：

首页 >

文章列表页 >

Quantitative electroencephalogram analysis in patients with semantic dementia

Correlation analysis of cognitive impairment and central biomarkers | 更新时间：2022-06-24

- Quantitative electroencephalogram analysis in patients with semantic dementia
- Journal of Shanxi Agricultural Sciences Vol. 46, Issue 11, Pages: 1366-1369(2021)
- 作者机构：
  
  1.中日友好医院神经科，北京　100029
  2.首都医科大学附属天坛医院认知障碍科、国家神经系统疾病临床医学研究中心，北京　100070
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002906
  CLC： R741
- Published：28 November 2021，
  
  Received：08 July 2021，
扫描看全文
Xiangfei Zhang, Pei Rong, Chunlei Hou, et al. Quantitative electroencephalogram analysis in patients with semantic dementia. [J]. Journal of Shanxi Agricultural Sciences 46(11):1366-1369(2021)
DOI：

Xiangfei Zhang, Pei Rong, Chunlei Hou, et al. Quantitative electroencephalogram analysis in patients with semantic dementia. [J]. Journal of Shanxi Agricultural Sciences 46(11):1366-1369(2021) DOI： 10.13406/j.cnki.cyxb.002906.

摘要

目的：

探讨语义性痴呆（semantic dementia，SD）患者的脑电图量化分析特点。

方法：

选取SD患者9例和性别年龄匹配的正常人30例进行脑电图（electroencephalogram，EEG）检查。记录EEG检查结果，测量全脑、左额、右额、左前颞叶、右前颞叶、左中后颞、右中后颞、左中央、右中央、左顶、右顶、左枕、右枕区各频段（δ+θ）/（α+β）相对功率比（DTABR）。对2组DTABR值及视觉分析结果进行比较，同时观察SD组患者EEG双侧大脑脑电活动的对称性。

结果：

与正常对照组相比，SD患者慢波活动增多，DTABR值增大，差异均有统计学意义（

0.01）。SD患者左侧DTABR值高于右侧对应部位，以前颞叶明显不对称为著，差异均有统计学意义（

0.05）。

结论：

定量EEG能够反映SD患者脑功能的变化，为理解SD的电生理学机制提供客观量化指标。

Abstract

Objective

To explore the characteristics of quantitative analysis of EEG in patients with semantic dementia (SD).

Methods

Nine SD patients and 30 normal controls sex and age matched were selected for electroencephalogram (EEG) examination. The results of the EEG data were visually scored and quantitatively analyzed. The relative power ratio of (δ+θ) / (α+β) (DTABR) at the whole brain

left and right frontal

anterior-temporal

middle-posterior temporal

center

parietal and occipital area was measured respectively. The value of DTABR and the result of visual analysis were compared between the two groups

and the symmetry of EEG activity of bilateral brain in SD patients was observed simultaneously.

Results

Compared with the normal control group

the slowwave activity and the DTABR of SD patients were significantly increased (

0.01). The DTABR on the left brain side was significantly higher than that on the right side in SD patients

especially on the anterior-temporal area (

0.05).

Conclusion

Quantitative EEG can reflect the changes in brain function of SD patients and provide objective quantitative indicators for exploring the electrophysiological mechanism of SD.

关键词

语义性痴呆定量脑电图额颞叶痴呆

Keywords

semantic dementiaquantitative electroencephalographyfrontotemporal dementia

references

Gorno-Tempini ML, Hillis AE, Weintraub S, et al. Classification of primary progressive aphasia and its variants[J]. Neurology, 2011, 76(11):1006-1014.

中华医学会老年医学分会老年神经病学组额颞叶变性专家. 额颞叶变性专家共识[J]. 中华神经科杂志, 2014, 47(5):351-356.

刘晓燕. 临床脑电图学[M]. 2版.北京: 人民卫生出版社, 2017: 40-41.

徐清, 徐文炜, 张玉琦, 等. 阿尔茨海默病与血管性痴呆定量脑电图波频差异研究[J]. 中国全科医学, 2013, 16(28):2584-2588.

Neary D, Snowden JS, Gustafson L, et al. Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria[J]. Neurology, 1998, 51(6):1546-1554.

Grieder M, Koenig T, Kinoshita T, et al. Discovering EEG resting state alterations of semantic dementia[J]. Clin Neurophysiol, 2016, 127(5):2175-2181.

Chen Y, Huang L, Chen KL, et al. White matter basis for the huband-spoke semantic representation: evidence from semantic dementia[J]. Brain, 2020, 143(4):1206-1219.

牛娜, 崔瑞雪, 张振馨. 语义性痴呆与进行性非流利失语患者18F-FDG PET/CT脑显像特征分析[J]. 中国神经免疫学和神经病学杂志, 2014, 21(5):314-318.

金轶, 周知, 李旭东, 等. 语义性痴呆患者脑99mTc-SPECT影像学特征分析[J]. 中日友好医院学报, 2018, 32(4):199-201, 205, 192.

Ding JH, Chen KL, Liu HM, et al. A unified neurocognitive model of the anterior temporal lobe contributions to semantics, language, social behaviour&face recognition[J]. Nat Commun, 2020, 11(1):2595.

Snowden JS, Harris JM, Thompson JC, et al. Semantic dementia and the left and right temporal lobes[J]. Cortex, 2018, 107:188-203.

Woollams AM, Patterson K. Cognitive consequences of the leftright asymmetry of atrophy in semantic dementia[J]. Cortex, 2018, 107:64-77.

周知, 钱端, 李旭东, 等. 语义性痴呆患者的临床、神经心理及影像学分析[J]. 中日友好医院学报, 2016, 30(1):3-6, 12, 2.

魏翠柏, 张玉婧, 周爱红, 等. 语义性痴呆的临床特点[J]. 中国神经精神疾病杂志, 2018, 44(8):449-452.

张诚, 韩臣柏, 王健, 等. 精神分裂症暴力违法行为患者定量脑电图比较研究[J]. 中华行为医学与脑科学杂志, 2010, 19(1):47-48.

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Cambridge semantic memory test battery applied research among patients with semantic dementia

Heterogeneity of frontotemporal lobar degeneration

Recent progress in semantic dementia

Related Author

Miaoxin Shen

Ziling Han

Weilin Zhang

Jinsong Jiao

Xudong Li

Xiaopeng Tong

Jia Jianjun

Sun Xuan

Related Institution

Department of Cognitive Disorders, Beijing Tiantan Hospital, Captital Medical University, China National Clinical Research Center for Neurological Disease

Department of Neurology, The Second Hospital of HeBei Medical University

Department of Neurology, China-Japan Friendship Hospital

Department of Basic Medical Sciences, Graduate School, Xizang Minzu University

Department of Geriatric Neurology,Chinese PLA General Hospital

⁰