The effect and mechanism of abnormal metabolism in parents on metabolism of offspring

Lin Xiaojing

doi:10.13406/j.cnki.cyxb.002889

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The effect and mechanism of abnormal metabolism in parents on metabolism of offspring

更新时间：2024-01-09

- The effect and mechanism of abnormal metabolism in parents on metabolism of offspring
- Journal of Chongqing Medical University Vol. 46, Issue 9, Pages: 1027-1030(2021)
- 作者机构：
  
  重庆医科大学附属第一医院重大代谢性疾病转化医学重点实验室,重庆,400016
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002889
  CLC： R589
- Published：2021，
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Lin Xiaojing. The effect and mechanism of abnormal metabolism in parents on metabolism of offspring. [J]. Journal of Chongqing Medical University 46(9):1027-1030(2021)
DOI：

Lin Xiaojing. The effect and mechanism of abnormal metabolism in parents on metabolism of offspring. [J]. Journal of Chongqing Medical University 46(9):1027-1030(2021) DOI： 10.13406/j.cnki.cyxb.002889.

摘要

代谢编程是指在人类和其他哺乳类动物胚胎期及分娩后各重要器官发育成熟的关键阶段。营养及其他环境因素能改变生物体内的表观遗传特征，从而影响这些器官的正常发育和成熟，使其在器官发育、物质代谢、免疫应激等方面发生相应改变，最终导致功能和代谢的永久改变，增加成年后多种慢性疾病发病的易感性。由于代谢编程异常的不利结局存在于两代人中间，并可能在“亲代—子代—亲代”之间形成恶性循环，所以其影响巨大，严重威胁几代人的健康，已成为全世界主要的健康与经济负担。肖晓秋研究团队多年来一直致力于打破这种恶性循环，本文就课题组已取得的研究进展进行工作综述，力图为从源头上控制代谢性疾病的发生和发展提供新的依据。

Abstract

Metabolic programming means that nutrition and other environmental factors can change the epigenetic characteristics of the organism during the embryonic period and key stages of the development and maturation of vital organs in humans and other mammals

thereby affecting the normal development and maturity of these organs. It makes corresponding changes in organ development

material metabolism

immune stress

etc.

which will eventually lead to permanent changes in function and metabolism

and increase the susceptibility of many chronic diseases in adulthood. Because the unfavorable outcome of abnormal metabolic programming exists between two generations

and may form a vicious circle between "parents-offspring-parents". It seriously threatens the health of several generations and has become a major issue in the world. Health and economic burden. Our research team has been committed to breaking this vicious circle for many years. This article reviews the research progress made by the research team and aims to provide a new basis for controlling the occurrence and development of metabolic diseases from the source.

关键词

亲代子代代谢异常肥胖糖尿病

Keywords

parentoffspringmetabolic abnormalityobesitydiabetes

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Related Institution

School of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine

Laboratory of Lipid & Glucose Metabolism，the First Affiliated Hospital of Chongqing Medical University

Teaching and Research Section of Nutrition and Food Hygiene，School of Public Health and Management，Chongqing Medical University

Teaching and Research Section of Clinical Biochemistry，Key Laboratory of Clinical Laboratory Diagnostics Founded by Ministry of Education，Chongqing Medical University

Department of Endocrinology，Armed Police Hospital of Chongqing

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