Correlation between polymorphism of α-synuclein gene and Parkinson's disease

Adila· Ainiwaer; La Zhang; Sen Jiang; Hua Gao; Wei Lou; Xinling Meng; Xinling Yang

doi:10.13406/j.cnki.cyxb.002873

您当前的位置：

首页 >

文章列表页 >

Correlation between polymorphism of α-synuclein gene and Parkinson's disease

Treatment of neurological diseases | 更新时间：2022-06-24

- Correlation between polymorphism of α-synuclein gene and Parkinson's disease
- Journal of Shanxi Agricultural Sciences Vol. 46, Issue 7, Pages: 844-848(2021)
- 作者机构：
  
  1.新疆医科大学第二附属医院神经内科，乌鲁木齐　830028
  2.新疆医科大学第五附属医院脑病科，乌鲁木齐　830011
  3.新疆医科大学第四附属医院脑病一科，乌鲁木齐　830054
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002873
  CLC： R742.5
- Published：28 July 2021，
  
  Received：26 February 2021，
扫描看全文
Adila· Ainiwaer, La Zhang, Sen Jiang, et al. Correlation between polymorphism of α-synuclein gene and Parkinson's disease. [J]. Journal of Shanxi Agricultural Sciences 46(7):844-848(2021)
DOI：

Adila· Ainiwaer, La Zhang, Sen Jiang, et al. Correlation between polymorphism of α-synuclein gene and Parkinson's disease. [J]. Journal of Shanxi Agricultural Sciences 46(7):844-848(2021) DOI： 10.13406/j.cnki.cyxb.002873.

摘要

目的：

探讨α-突触核蛋白基因（α-synuclein gene，

SNCA

）rs1372525、rs3822086等位点基因多态性与新疆地区帕金森病的关联性。

方法：

采用病例-对照研究，收集来自新疆医科大学各个附属医院门诊及病区225例帕金森病患者及231例年龄、性别、生源地等条件与其相匹配的健康体检者，分别作为病例组及对照组；采集2组参与者外周血液，通过提取脱氧核糖核酸（deoxyribonucleic acid，DNA），聚合酶链反应（polymerase chain reaction，PCR）对2组参与者的

SNCA

rs1372525、rs3822086等位点进行多态分析。

结果：

病例组与对照组

SNCA

rs1372525位点分别测得AA型161、164例，AG型54、61例，GG型10、6例，等位基因A的频率分别为83.6%和84.2%，等位基因G在2组间的频率分别为16.4%和15.8%，rs1372525位点3种基因型及等位基因分布频率在帕金森病组与对照组间的差异无统计学意义（

0.05）。病例组与对照组rs3822086位点分别测得CC型47、73例，CT型115、113例，TT型63、45例，等位基因C的频率为46.4%、56.1%，等位基因T的频率为53.6%、43.9%，可见该位点rs3822086 CC基因型和等位基因C在2组间的差异无统计学意义（

0.05）；而CT、TT 2种基因型及等位基因T的分布频率在2组之间的差异有统计学意义（

0.05）。

结论：

SNCA

rs1372525位点多态性与帕金森病的发病无关。rs3822086考虑是帕金森病发生发展中的易感位点之一。

Abstract

Objective

To investigate the correlation between the susceptibility of rs1372525 and rs3822086 polymorphisms of αsynuclein gene (

SNCA

) and Parkinson's disease in Xinjiang.

Methods

A case-control study was conducted to collect the peripheral blood of 225 outpatients with Parkinson's disease from the Affiliated Hospitals of Xinjiang Medical University and 231 healthy subjects matched with age

gender and place of birth. The patients were divided as the case group and the control group. The peripheral blood of two groups of participants were collected

and the polymorphism of SNCA rs1372525 and rs3822086 loci were analyzed by deoxyribonucleic acid (DNA) amplification and polymerase chain reaction (PCR).

Results

The

SNCA

rs1372525 loci of the case group and the control group were respectively detected in 161 and 164 cases of AA type

54 and 61 cases of AG type

and 10 and 6 cases of GG type. The frequency of allele A was 83.6% and 84.2% respectively

and the frequency of allele G was 16.4% and 15.8%. There was no significant difference in the distribution frequency of genotypes and alleles between the case group and the control group (

0.05). There were 47 and 73 cases of CC type

115 and 113 cases of CT type and 63 and 45 cases of TT type detected at rs3822086 locus in case group and control group

respectively. The frequency of allele C was 46.4% and 56.1%

and the frequency of allele T was 53.6% and 43.9%

respectively. There was no significant difference in rs3822086 CC genotype and allele C between the two groups (

0.05). However

there were significant differences in the distribution frequency of CT and TT genotypes and allele T between the two groups (

0.05).

Conclusion

There is no correlation between

SNCA

rs1372525 locus polymorphism and the incidence of Parkinson's disease

and rs3822086 locus is considered as one of the susceptible sites in the occurrence and development of Parkinson's disease.

关键词

帕金森病α-突触核蛋白α-突触核蛋白基因rs1372525rs3822086

Keywords

Parkinson'sdiseaseα-synucleinα-synucleingeners1372525rs3822086

references

Dorsey ER, Bloem BR. The Parkinson pandemic: a call to action[J]. JAMA Neurol, 2018, 75(1):9-10.

Stoker TB, Barker RA. Recent developments in the treatment of Parkinson's disease[J]. F1000Res, 2020, 9:F1000.

Schrag A, Anastasiou Z, Ambler G, et al. Predicting diagnosis of Parkinson's disease: a risk algorithm based on primary care presentations[J]. Mov Disord, 2019, 34(4):480-486.

Kalinderi K, Bostantjopoulou S, Fidani L. The genetic background of Parkinson's disease: current progress and future prospects[J]. Acta Neurol Scand, 2016, 134(5):314-326.

Du B, Xue Q, Liang C, et al. Association between alpha-synuclein(SNCA)rs11931074 variability and susceptibility to Parkinson's disease: an updated Meta-analysis of 41 811 patients[J]. Neurol Sci, 2020, 41(2):271-280.

Chang D, Nalls MA, Kerchner GA, et al. A meta-analysis of genomewide association studies identifies 17 new Parkinson's disease risk loci[J]. Nat Genet, 2017, 49(10):1511-1516.

Liu Y, Bai H, Gen S, et al. Interaction between SNCA gene polymorphisms and T2DM with Parkinson's disease[J]. Acta Neurol Scand, 2020, 142(5):443-448.

Guo XY, Chen YP, Song W, et al. SNCA variants rs2736990 and rs356220 as risk factors for Parkinson's disease but not for amyotrophic lateral sclerosis and multiple system atrophy in a Chinese population[J]. Neurobiol Aging, 2014, 35(12):2882.e1-2882.e6.

Chen Y, Wei QQ, Ou R, et al. Genetic variants of SNCA are associated with susceptibility to Parkinson's disease but not amyotrophic lateral sclerosis or multiple system atrophy in a Chinese population[J]. PLoS One, 2015, 10(7):e0133776.

甘蓉, 张玉虎, 聂坤, 等. α突触核蛋白基因多态性与帕金森病及其认知障碍的相关性研究[J]. 中华老年心脑血管病杂志, 2012, 14(8):788-791.

Myhre R, Toft M, Kachergus J, et al. Multiple alpha-synuclein gene polymorphisms are associated with Parkinson's disease in a Norwegian population[J]. Acta Neurol Scand, 2008, 118(5):320-327.

Hughes AJ, Daniel SE, Kilford L, et al. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases[J]. J Neurol Neurosurg Psychiatry, 1992, 55(3):181-184.

谢云, 周韧, 叶月纺, 等. 浙江地区汉族人群caspase-3基因三个位点的单倍型研究[J]. 中华医学遗传学杂志, 2004, 21(6):633-635.

Das Chagas Campêlo CL, Silva RH. Genetic variants in SNCA and the risk of sporadic Parkinson's disease and clinical outcomes: a review[J]. Parkinsons Dis, 2017, 2017:4318416.

Melki R. Alpha-synuclein and the prion hypothesis in Parkinson's disease[J]. Rev Neurol(Paris), 2018, 174(9):644-652.

Pihlstrm L, Blauwendraat C, Caooelletti C, et al. A comprehensive analysis of SNCA-related genetic risk in sporadic Parkinson disease[J]. Ann Neurol, 2018, 84(1):117-129.

Thornton-Wells TA, Moore JH, Haines JL. Genetics, statistics and human disease: analytical retooling for complexity[J]. Trends Genet, 2004, 20(12):640-647.

Moore JH. The ubiquitous nature of epistasis in determining susceptibility to common human diseases[J]. Hum Hered, 2003, 56(1-3):73-82.

Sing CF, Stengard JH, Kardia SL. Dynamic relationships between the genome and exposures to environments as causes of common human diseases[J]. World Rev Nutr Diet, 2004, 93:77-91.

查看原文

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

The establishment of chronic parkinson’s desease in mouse model induded by mptp

Related Author

LUO Qin

et al

王加才

王少君

Related Institution

Department of Neurology,the First People’s Hospital of Zigong

重庆医科大学附属第一医院神经内科、重庆市神经病学重点实验室

⁰