Objective:To study the effect of resveratrol（RES） on left ventricular remodeling in spontaneous hypertension rat（SHR）and its role in silent information regulator 1/nuclear transcription factor-κB（SIRT1/NF-κB） signaling pathway.Methods:Eight male Wi star-Kyoto（WKY） rats aged 8 weeks were taken as the normal group（WKY group）

and 40 male SHR aged 8 weeks were randomly divided into SHR group

RES group

EX527 group

RES+EX527 group

and RES+pyrrolidine dithiocarbamate（PDTC） group

with 8 rats in each group

given corresponding drug intervention for 12 weeks.The rats’ weight

systolic pressure

echocardiography

left ventricular mass

left ventricular mass index（LVMI）

myocardial collagen volume fraction（CVF）

oxidative stress index

SIRT1 and NF-κB protein expression levels

and inflammatory factors protein expression levels were measured.And the morphological and pathological changes of the heart under HE and Masson staining were observed.Results:Compared with WKY group[LVMI（2.12±0.10） mg/g

CVF（0.18±0.09）%

SIRT1 protein expression（1.40±0.05）

NF-κB protein expression（0.46±0.06）]

SHR group[LVMI（3.07±0.07） mg/g

CVF（2.60±0.56）%

SIRT1 protein expression（0.78±0.08）

NF-κB protein expression（1.41±0.08）]showed severe left ventricular remodeling

significantly increased levels of oxidative stress and inflammatory factors as well as NF-κB expression（P<0.05）

and decreased SIRT1 expression（P<0.05）.In RES group[LVMI（2.72±0.09） mg/g

CVF（1.10±0.30）%

SIRT1 protein expression（0.99±0.07）

NF-κB protein expression（0.98±0.12）]

compared with SHR group

left ventricular remodeling degree was reduced

oxidative stress and inflammatory factors as well as NF-κB expression levels were decreased（P<0.05）

and SIRT1 expression was increased（P<0.05）.The results of EX527 group [LVMI（3.18±0.08） mg/g

CVF（2.83±0.98）%

SIRT1 protein expression（0.60±0.02）

NF-κB protein expression（1.68±0.07）]were opposite to those of RES group.Compared with RES group

RES+EX527 group showed a trend of reversing RES to ameliorate left ventricular remodeling.RES+PDTC group showed a tendency to further ameliorate left ventricular remodeling.Conclusion:RES can ameliorate left ventricular remodeling of SHR

and its mechanism may be related to regulation of SIRT1/NF-κB pathway to reduce oxidative stress and inflammatory response damage.