Correlation between HPV infection and prognosis of endocervical adenocarcinoma

doi:10.13406/j.cnki.cyxb.002826

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Correlation between HPV infection and prognosis of endocervical adenocarcinoma

更新时间：2024-01-09

- Correlation between HPV infection and prognosis of endocervical adenocarcinoma
- Journal of Chongqing Medical University Vol. 46, Issue 6, Pages: 700-703(2021)
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- DOI：10.13406/j.cnki.cyxb.002826
  CLC： R737.33
- Published：2021，
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Correlation between HPV infection and prognosis of endocervical adenocarcinoma. [J]. Journal of Chongqing Medical University 46(6):700-703(2021)
DOI：

Correlation between HPV infection and prognosis of endocervical adenocarcinoma. [J]. Journal of Chongqing Medical University 46(6):700-703(2021) DOI： 10.13406/j.cnki.cyxb.002826.

摘要

目的：本研究将宫颈特殊类型腺癌分为人乳头瘤状病毒（human papillomavirus，HPV）感染相关型和非HPV感染相关型，探讨不同分型与预后的关系。方法：收集美国SEER数据库共468例宫颈特殊类型腺癌患者的临床资料进行回顾性分析，将其分为HPV感染相关型（HPV-associated adenocarcinoma，HPVA）组和非HPV感染相关型（non-HPV-associated adenocarcinoma，NHPVA）组，采用卡方检验、Fisher检验、K-M法、log-rank检验、Cox回归模型进行统计学分析。结果：组间比较结果显示2组患者在分期、肿瘤分化程度方面有明显统计学差异。NHPVA组比HPVA组期别更晚（P=0.001），肿瘤分化更差（P<0.05）。肿瘤相关死亡率在NHPVA组（70/205，34.1%）明显高于HPVA组（53/263，20.2%），NHPVA组总体预后差于HPVA组（P=0.001）。5个病理亚型间预后差异有明显统计学意义（P=0.002），浆液性癌预后最差。结论：基于是否感染HPV对宫颈特殊类型腺癌进行分类能预测患者预后，从而采取相应治疗措施，将对临床工作产生一定指导意义。

Abstract

Objective: To analyze the prognostic relationship between Human papillomavirus (HPV) -infection and endocervical adenocarcinoma (ECA) of the uterine cervix

so as to provide a reference for clinical work. Methods: Clinical data of 468 ECA patients screened from SEER Database were divided into HPVA (HPV-associated adenocarcinoma) and NHPVA (non-HPV-associated Adenocarcinoma) group

followed by a retrospective analysis

which were statistically analyzed using Chi-square test

Fisher test

K-M method

log-rank test and Cox regression. Results: There were significant differences in stage and tumor differentiation grade between the two groups. Compared with HPVA group

the stage of NHPVA group was later (P=0.001)

and the tumor differentiation was worse (P<0.05). The NHPVA group had a significantly higher cancer-related mortality (70/205

34.1%) than HPVA group (53/263

20.2%). The prognosis was significantly worse in NHPVA group than HPVA group (P=0.001). The cancer-related mortality was significantly different (P=0.002) within the 5 sub-groups of mucinous

gastic type

villoglandular

clear cell

and serous carcinoma

while the serous type had the worst prognosis. Conclusion: It is important to classify the ECA into HPVA and NHPVA for clinical work in the future.

关键词

宫颈管型腺癌HPV感染相关型非HPV感染相关型生存分析

Keywords

endocervical adenocarcinomaHPV-associated adenocarcinomanon-HPV-associated adenocarcinomasurvival analysis

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