Investigation of risk factors for venous thromboembolism in women with ovarian malignant tumor

Liu Changhao

doi:10.13406/j.cnki.cyxb.002812

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Investigation of risk factors for venous thromboembolism in women with ovarian malignant tumor

更新时间：2024-01-09

- Investigation of risk factors for venous thromboembolism in women with ovarian malignant tumor
- Journal of Chongqing Medical University Vol. 46, Issue 6, Pages: 655-658(2021)
- 作者机构：
  
  中山大学孙逸仙纪念医院妇产科,广州,510000
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002812
  CLC： R713.6
- Published：2021，
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Liu Changhao. Investigation of risk factors for venous thromboembolism in women with ovarian malignant tumor. [J]. Journal of Chongqing Medical University 46(6):655-658(2021)
DOI：

Liu Changhao. Investigation of risk factors for venous thromboembolism in women with ovarian malignant tumor. [J]. Journal of Chongqing Medical University 46(6):655-658(2021) DOI： 10.13406/j.cnki.cyxb.002812.

摘要

目的：研究卵巢恶性肿瘤患者发生静脉血栓栓塞症（venous thromboembolism，VTE）的危险因素。方法：回顾性分析2015年1月1日至2018年6月30日中山大学孙逸仙纪念医院妇科肿瘤专科收治的345例卵巢恶性肿瘤患者资料，其中31例发生VTE，314例未发生VTE。比较卵巢恶性肿瘤患者的年龄、身高、体质量、病理分期、病理类型、肿瘤标志物水平等，以研究卵巢恶性肿瘤患者发生静脉血栓的危险因素。结果：卵巢恶性肿瘤合并VTE组与无VTE组的年龄和手术病理分期差异有统计学意义（P<0.05）；体质指数（body mass index，BMI）、病理类型的差异无统计学意义（P>0.05）。2组血肿瘤标志物（AFP、CEA、CA125、CA199、CA724、HE4）水平差异均无统计学意义（P>0.05）。Logistic分析提示手术病理分期是卵巢恶性肿瘤合并VTE的独立危险因素。结论：年龄和分期是卵巢恶性肿瘤合并VTE的危险因素，对年龄大以及肿瘤晚期的患者应重点预防和监测血栓的发生。

Abstract

Objective: To clarify the risk factors for venous thromboembolism (VTE) in women with ovarian malignant tumor. Methods: The data of 345 patients with ovarian malignant tumor admitted to the department of gynecological oncology of Sun Yat-sen Memorial Hospital

Sun Yat-sen University from January 1

2015 to June 30

2018 were analyzed retrospectively

among which 31 cases had VTE and 314 cases didn't. The patients'age

height

weight

surgical-pathological stage

pathological type and level of tumor markers were compared

so as to study the risk factors of VTE in patients with ovarian malignant tumor. Results: Our analysis showed that there were significant differences in surgical-pathological stage and age among the ovarian malignant tumor patients with VTE and those without (P<0.05)

and there was no significant difference between body mass index (BMI) and pathology type (P>0.05). There was also no significant difference among tumor markers (AFP

CEA

CA125

CA199

CA724

HE4) (P>0.05).Logistic analysis suggested that surgical-pathological stage was an independent risk factor of VTE in women with ovarian malignant tumor. Conclusion: Age and surgical-pathological stage are risk factors of VTE in women with ovarian malignant tumor. The prevention and monitoring of thrombosis should be focused on the elderly and patients with advanced tumor.

关键词

卵巢恶性肿瘤静脉血栓危险因素

Keywords

ovarian malignant tumorvenous thromboembolismrisk factor

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