Patients with advanced pancreatic cancer are often accompanied by moderate to severe pain

which greatly reduces the quality of life and even shortens the survival time. Early perineural invasion is the main cause of patients'%short survival time and moderate to severe pain. The involvement of various inflammatory cells in neurotumor microenvironment promotes the proliferation and migration of tumor cells to varying degrees

and then pain signal substances and pain channels in molecular pathways are multiply produced

resulting in severe pain in patients. With the further study of various signaling pathways

nerve growth factors and receptor pathways

chemokines

pain channels and non-coding mRNA are potential therapeutic targets. In this paper

the pain mechanism of pancreatic cancer is summarized

which provides reference for the subsequent research on the mechanism and development of therapeutic targets.