Progress of gut microbiota in neurodegenerative diseases

Fang Sheng; Chu Guanghui; Yuan Yukai; Zhou Zheng; Fu Yu

doi:10.13406/j.cnki.cyxb.002770

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Progress of gut microbiota in neurodegenerative diseases

更新时间：2024-01-09

- Progress of gut microbiota in neurodegenerative diseases
- Journal of Chongqing Medical University Vol. 46, Issue 5, Pages: 508-512(2021)
- 作者机构：
  
  昆明理工大学医学院基础医学部,昆明,650500
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002770
  CLC： Q36;Q933;R741
- Published：2021，
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Fang Sheng, Chu Guanghui, Yuan Yukai, et al. Progress of gut microbiota in neurodegenerative diseases. [J]. Journal of Chongqing Medical University 46(5):508-512(2021)
DOI：

Fang Sheng, Chu Guanghui, Yuan Yukai, et al. Progress of gut microbiota in neurodegenerative diseases. [J]. Journal of Chongqing Medical University 46(5):508-512(2021) DOI： 10.13406/j.cnki.cyxb.002770.

摘要

肠道微生物可以影响中枢神经系统。肠道微生物能够调节神经系统、内分泌系统、免疫系统等，进而影响神经退行性疾病的发生发展。本文总结了肠道微生物研究的发展历史，重点综述了近年来阿尔茨海默病、帕金森病、肌萎缩侧索硬化等神经退行性疾病在肠道微生物上的研究进展。肠道微生物稳态的破坏是影响神经退行性疾病发生发展的重要因素，而重构肠道微生物稳态，如抗生素与益生菌治疗，以及粪便移植等方式或可成为神经退行性疾病治疗研究的新方向。

Abstract

Gut microbiota interacts with the central neural system. Gut microbiota can regulate neural system

endocrine system

and immune system

etc.

thus leading to the progress of neurodegenerative diseases. This paper reviews the research history of the gut microbiota

and focuses on its current progress in neurodegenerative diseases including Alzheimer's disease

Parkinson disease and amyotrophic lateral sclerosis. Accumulating evidence indicates that the gut microbial homeostasis may be destroyed in neurodegenerative diseases. Therefore

the maintenance of normal gut microbial homeostasis

such as by antibiotic and probiotic therapy and fecal transplantation

will provide new ways and ideas for the prevention and treatment of these kind of diseases.

关键词

肠道微生物神经退行性疾病阿尔茨海默病帕金森病

Keywords

gut microbiotaneurodegenerative diseasesAlzheimer's diseaseParkinson disease

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