Advances in research on biomarkers and prediction of cerebral infarction hemorrhage transformation

Wang Siqi; Feng Jinwen; Meng Qiang

doi:10.13406/j.cnki.cyxb.002741

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Advances in research on biomarkers and prediction of cerebral infarction hemorrhage transformation

更新时间：2024-01-09

- Advances in research on biomarkers and prediction of cerebral infarction hemorrhage transformation
- Journal of Chongqing Medical University Vol. 46, Issue 5, Pages: 526-528(2021)
- 作者机构：
  
  昆明理工大学医学院,昆明,650504
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002741
  CLC： R543
- Published：2021，
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Wang Siqi, Feng Jinwen, Meng Qiang. Advances in research on biomarkers and prediction of cerebral infarction hemorrhage transformation. [J]. Journal of Chongqing Medical University 46(5):526-528(2021)
DOI：

Wang Siqi, Feng Jinwen, Meng Qiang. Advances in research on biomarkers and prediction of cerebral infarction hemorrhage transformation. [J]. Journal of Chongqing Medical University 46(5):526-528(2021) DOI： 10.13406/j.cnki.cyxb.002741.

摘要

在缺血性中风的发病机制中，由于内皮细胞等血脑屏障结构破坏、再灌注损伤、溶栓药治疗后凝血功能障碍等，恢复的血流从破坏的血管进入脑组织中，称为出血转化（haemorrhagic transformation，HT）。严重的HT是导致患者死亡的原因之一。研究发现多种因素可能与HT有关，如高龄、糖尿病、患者病情严重等。能否由生物学标记物定量确定HT概率，并通过管理减少HT，将为临床HT的防治提供帮助。为此，本文就该方面的研究进展进行综述。

Abstract

In the pathogenesis of ischemic stroke

due to the breakdown of blood-brain barrier structures such as endothelial cells

reperfusion injury

and coagulation dysfunction after thrombolytic therapy

etc.

the restored blood flow enters the brain tissue from the damaged blood vessels

which is called hemorrhagic transformation (HT). Severe HT is one of the causes of death in patients. Researches find that HT may be related to many factors

such as venerable age

diabetes

and the severity of the patient's condition. It will be helpful for the prevention and treatment of clinical HT whether the probability of HT can be determined quantitatively by biological markers and reduced by management. Therefore

this paper reviews the advances in this area.

关键词

出血转化病理机制嗜酸性粒细胞绝对值组织蛋白酶K血尿素氮/肌酐比值活性氧

Keywords

haemorrhagic transformationpathological mechanismabsolute eosinophil valuecathepsin Kblood urea nitrogen/creatinineratioreactive oxygen species

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