Research progress on the role of SOCS-3 in liver diseases

Yan Yuanzhi; Yang Zhe; Hu Xidan; Ma Kaili; Tang Heng; You Jing

doi:10.13406/j.cnki.cyxb.002726

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Research progress on the role of SOCS-3 in liver diseases

更新时间：2021-10-08

- Research progress on the role of SOCS-3 in liver diseases
- Journal of Chongqing Medical University (2021)
- 作者机构：
  
  1. 国家卫健委毒品依赖和戒治重点实验室昆明医科大学第一附属医院药剂科
  2. 国家卫健委毒品依赖和戒治重点实验室昆明医科大学第一附属医院病理科
  3. 中国医学科学院医学生物学研究所药物安全性评价研究中心
  4. 国家卫健委毒品依赖和戒治重点实验室昆明医科大学第一附属医院感染性疾病和肝病科
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002726
  CLC： R575;R735.7;R512.6
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[1]晏远智,杨哲,胡曦丹,马开利,唐恒,游晶.SOCS-3在肝脏疾病中的作用研究进展[J/OL].重庆医科大学学报:1-4[2021-03-11].https://doi.org/10.13406/j.cnki.cyxb.002726.

Yan Yuanzhi, Yang Zhe, Hu Xidan, et al. Research progress on the role of SOCS-3 in liver diseases. [J/OL]. Journal of Chongqing Medical University (2021)
[1]晏远智,杨哲,胡曦丹,马开利,唐恒,游晶.SOCS-3在肝脏疾病中的作用研究进展[J/OL].重庆医科大学学报:1-4[2021-03-11].https://doi.org/10.13406/j.cnki.cyxb.002726. DOI：

Yan Yuanzhi, Yang Zhe, Hu Xidan, et al. Research progress on the role of SOCS-3 in liver diseases. [J/OL]. Journal of Chongqing Medical University (2021) DOI： 10.13406/j.cnki.cyxb.002726.

摘要

细胞因子信号转导抑制蛋白-3（suppressor of cytokine signaling

SOCS-3）是一种细胞因子信号转导阻抑蛋白

参与体内多种信号转导通路的调节。研究发现

SOCS-3与肝纤维化、病毒性肝炎和肝肿瘤的发生发展均存在一定的关系

并且干扰素的抗病毒疗效与SOCS-3的遗传学表达改变密切相关。本综述将对SOCS-3的结构、分子功能及近年来在肝疾病中的相关研究进行简要总结。

Abstract

Suppressor of cytokine signaling-3(SOCS-3) is a kind of cytokine signaling transduction inhibitory protein

involving in the regulation of multiple signal transduction pathways in vivo.It’s found that SOCS-3 plays an important role in the occurrence and development of liver fibrosis

viral hepatitis and liver tumors

and the antiviral efficacy of interferon is closely related to the genetic expression of SOCS-3.This review briefly summarizes the structure and molecular function of SOCS-3 and related research in liver diseases in recent years.

关键词

SOCS-3JAK/STAT信号通路病毒性肝炎肝纤维化肝细胞癌肝脏疾病

Keywords

SOCS-3JAK/STAT signaling pathwayviral hepatitisliver fibrosishepatocellular carcinomaliver diseases

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