Study progress on pathogenesis and treatments of inflammation in diabetic kidney disease

Hu Chun; Wu Xiaoyan

doi:10.13406/j.cnki.cyxb.002672

您当前的位置：

首页 >

文章列表页 >

Study progress on pathogenesis and treatments of inflammation in diabetic kidney disease

更新时间：2024-01-09

- Study progress on pathogenesis and treatments of inflammation in diabetic kidney disease
- Journal of Chongqing Medical University Vol. 46, Issue 5, Pages: 618-624(2021)
- 作者机构：
  
  武汉大学中南医院肾内科,武汉,430071
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002672
  CLC： R587.2
- Published：2021，
扫描看全文
Hu Chun, Wu Xiaoyan. Study progress on pathogenesis and treatments of inflammation in diabetic kidney disease. [J]. Journal of Chongqing Medical University 46(5):618-624(2021)
DOI：

Hu Chun, Wu Xiaoyan. Study progress on pathogenesis and treatments of inflammation in diabetic kidney disease. [J]. Journal of Chongqing Medical University 46(5):618-624(2021) DOI： 10.13406/j.cnki.cyxb.002672.

摘要

糖尿病肾病（diabetic kidney disease，DKD）是糖尿病的严重并发症，也是常见的继发性慢性肾脏疾病（chronic kidney disease，CKD）以及引起终末期肾功能衰竭的主要病因。DKD的具体发病机制尚不清楚，与多种因素有关。目前研究显示，炎症反应在DKD发生发展中起重要作用。本文探讨了相关炎症分子和信号通路在DKD进展中的作用。同时，本文综述了针对细胞因子、趋化因子、转录因子、激酶和促炎症消退的分子的靶向药物和几种具有抗炎作用的化合物对DKD的有益作用。因此，通过抑制这些炎症因子、炎症信号通路及其下游产物以及针对促炎症消退的分子，可能为DKD防治提供新的途径和措施。

Abstract

Diabetic kidney disease (DKD) is a serious complication of diabetes mellitus

and it's also a common type of secondary chronic kidney disease (CKD) as well as the main cause of end stage renal failure. The specific pathogenesis of DKD is not well understood yet

which is related to many factors

and current research indicates that inflammation plays an important role in the development and progression of DKD. This review summarizes the role of relevant inflammatory molecules and signaling pathways in the progression of DKD. At the same time

we also have reviewed the beneficial effects of several drugs targeting cytokines

chemokines

transcription factors

kinases and molecules that promote the resolution of inflammation as well as several anti-inflammatory compounds on DKD. Therefore

the use of targeted drugs against these inflammatory factors

inflammatory signaling pathways and their downstream products as well as molecules that promote the resolution of inflammation to control inflammation may become a new approach and measure for DKD treatment in the future.

关键词

糖尿病肾病炎症反应抗炎症治疗

Keywords

diabetic kidney diseaseinflammatory reactionanti-inflammatory therapy

references

查看原文

Views

1182

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Research progress of related gene polymorphism of diabetic nephropathy

Correlation between the levels of serum HMGB1 and TNF-α and cardiac function in patients with diabetic kidney disease

Arterial stiffness in non-dialysis patients with diabetic kidney disease and its influence on prognosis

Nomogram prediction model of type 2 diabetes mellitus-carotid atherosclerosispatients complicated with diabetic kidney disease

Related Author

Han Rui

Ma Qiang

Liu Zehui

Yang Mengru

Ma Sha

Zhou Ying

Chen Juan

Gao Pengxia

Related Institution

The Second Department of Endocrinology，The First Affiliated Hospital of Kunming Medical University

Department of Nephrology, The Affiliated Huai'an No.1 People’s Hospital of Nanjing Medical University

Department of Endocrinology, The Affiliated Huai'an No.1 People’s Hospital of Nanjing Medical University

Department of ECG, The Affiliated Huai'an No.1 People’s Hospital of Nanjing Medical University

Department of Nephrology，People’s Hospital of Peking University

⁰