Progress in overcoming tumor hypoxia and enhancing the efficacy of photodynamic therapy

doi:10.13406/j.cnki.cyxb.002656

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Progress in overcoming tumor hypoxia and enhancing the efficacy of photodynamic therapy

更新时间：2024-01-09

- Progress in overcoming tumor hypoxia and enhancing the efficacy of photodynamic therapy
- Journal of Chongqing Medical University Vol. 46, Issue 9, Pages: 1054-1057(2021)
- 作者机构：
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002656
  CLC： R730.57
- Published：2021，
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Progress in overcoming tumor hypoxia and enhancing the efficacy of photodynamic therapy. [J]. Journal of Chongqing Medical University 46(9):1054-1057(2021)
DOI：

Progress in overcoming tumor hypoxia and enhancing the efficacy of photodynamic therapy. [J]. Journal of Chongqing Medical University 46(9):1054-1057(2021) DOI： 10.13406/j.cnki.cyxb.002656.

摘要

光动力疗法（photodynamic therapy，PDT）因其高安全性已广泛应用于临床。PDT过程具有高度氧依赖性，而缺氧作为实体肿瘤的特征，显著中和了PDT疗效，限制其在抵抗实体肿瘤上的应用。近年来，许多策略都致力于克服肿瘤缺氧这一“致命弱点”。本文综述了不同克服肿瘤缺氧的方法在增效PDT方面的最新进展。

Abstract

Photodynamic therapy (PDT) has been widely used in clinic due to its high safety. The PDT process is highly oxygen-depended

however

hypoxia

as a characteristic of solid tumors

significantly neutralizes the PDT efficacy and limits its application in resisting solid tumors. In recent years

tremendous strategies have been devoted to overcoming the "fatal weakness"

tumor hypoxia. In this paper

the latest progress of overcoming tumor hypoxia in enhancing the PDT efficacy are reviewed.

关键词

肿瘤缺氧光动力治疗

Keywords

tumorhypoxiaphotodynamic therapy

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Related Author

Ren Meiping

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Tang Ni

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Related Institution

Drug Discovery Research Center，Department of Cardiovascular Medicine，Southwest Medical University

Key Laboratory of Molecular Biology of Infectious Diseases，Ministry of Education，Chongqing Medical University

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Center for Intelligent Testing and Molecular Medicine， School of Medicine， Chongqing University

Department of Stomatology,the Children’s Hospital,Chongqing Medical University

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