Research progress on therapeutic value of activating peroxisome proliferator-activated receptor-gamma on secondary brain injury after intracerebral hemorrhage

Wu Qian; Wang Likun; Wu Guofeng

doi:10.13406/j.cnki.cyxb.002538

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Research progress on therapeutic value of activating peroxisome proliferator-activated receptor-gamma on secondary brain injury after intracerebral hemorrhage

更新时间：2024-01-09

- Research progress on therapeutic value of activating peroxisome proliferator-activated receptor-gamma on secondary brain injury after intracerebral hemorrhage
- Journal of Chongqing Medical University Vol. 46, Issue 5, Pages: 529-532(2021)
- 作者机构：
  
  贵州医科大学临床医学院,贵州,550004
- 作者简介：
- 基金信息：
- DOI：10.13406/j.cnki.cyxb.002538
  CLC： R574.2
- Published：2021，
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Wu Qian, Wang Likun, Wu Guofeng. Research progress on therapeutic value of activating peroxisome proliferator-activated receptor-gamma on secondary brain injury after intracerebral hemorrhage. [J]. Journal of Chongqing Medical University 46(5):529-532(2021)
DOI：

Wu Qian, Wang Likun, Wu Guofeng. Research progress on therapeutic value of activating peroxisome proliferator-activated receptor-gamma on secondary brain injury after intracerebral hemorrhage. [J]. Journal of Chongqing Medical University 46(5):529-532(2021) DOI： 10.13406/j.cnki.cyxb.002538.

摘要

脑出血发生数小时至数天内，由红细胞裂解产物引起的氧化反应、炎症反应及线粒体功能障碍将导致继发性脑损伤。过氧化物酶增殖物激活受体-γ（peroxisome proliferator-activated receptor-gamma，PPAR-γ）在内源性血肿清除系统中发挥多重作用，激活PPAR-γ后不仅在抗炎抗氧化方面发挥作用，还在介导吞噬细胞清除血肿方面发挥作用，因此激活PPAR-γ可能是治疗脑出血后继发性脑损伤的一个潜在靶点。

Abstract

Oxidative reaction

inflammatory action

and mitochondrial dysfunction caused by erythrocyte lysates will lead to secondary brain injury within hours to days of cerebral hemorrhage. It has been found recently that peroxisome proliferator-activated receptorgamma (PPAR-γ) plays multiple roles in endogenous hematoma clearance systems. When PPAR-γ is activated

it not only plays a role in anti-inflammatory and anti-oxidation

but also mediates the role of phagocytic cells in clearing hematoma to protect neurons. Therefore

PPAR-γ may be a potential target for the treatment of secondary brain injury after intracerebral hemorrhage.

关键词

脑出血继发性脑损伤过氧化物酶增殖物激活受体-γ小胶质细胞清道夫受体

Keywords

intracerebral hemorrhagesecondary brain injuryperoxisome proliferator-activated receptor-γmicrogliascavenger receptor

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