Objective: To study the surgical effect of radiofrequency ablation combined with left atrial appendage closure in treating valvular disease complicated with atrial fibrillation. Methods: A total of 120 patients with cardiac mitral valve disease and atrial fibrillation in our hospital were collected and divided into the study group-patients after mitral valve surgery with concomitant radiofrequency surgical ablation and left atrial appendage closure (56 cases)

and the control group-patients undergoing only mitral valve surgery (64 cases) according to the type of operation. Operation indicators

sinus rhythm restoration rates

cardiac function

correlation factors in blood and complications were observed. Results: The operation time and cardiopulmonary bypass time in the study group were longer than those in the control group (t=3.129

P=0.002; t=5.873

P=0.000)

and other indexes were not different. The sinus rhythm restoration rate in the study group was 83.3%at the end of the operation

57.4%at the 3rd day after operation

59.3%before discharging hospital

72.2%at the 3rd month after operation

74.1%at 6th months after operation and 75.9%at one year after operation; the sinus rhythm restoration in the control group were 14.5%at the end of the operation

11.3%at the 3rd day after operation

11.3%before discharging hospital

8.1%at the 3rd month after operation

9.7%at the 6th month after operation and 8.1%at one year after operation

with statistically significant differences (P=0.000). The cardiac function and factors in blood in the study group were better than those in the control group. According to follow-up

the incidence of complications (cerebral infarction and hemorrhage) in the study group was lower than that of the control group (χ2=4.551

P=0.033; χ2=5.716

P=0.017). Conclusion: Radiofrequency ablation combined with left atrial appendage closure in treating valvular disease complicated with atrial fibrillation is safe

with significance in preventing thromboembolism.