Objective:To investigate the change level of thrombospondin 1/2（TSP1/2）and matrix metalloproteinase 2/9（MMP2/9）in patients with acute hypertensive intracerebral hemorrhage（HICH）and its clinical significance.Methods:The 52 patients with HICH within 24 hours from onset diagnosed with head CT as experimental group and 52 cases of physical examination in the same period were collected as the normal value prospectively.In HICH group

brain hematoma volume and edema volume were calculated by CT detection

and TSP1/2 and MMP2/9 levels in serum were determined on days 1

3

7

14 after onsets.Results:（1）The level of TSP1/2 and MMP2/9 in serum of the HICH group was significantly increased than the normal value at each time point.TSP1 and TSP2 reached the peak on the 3 d [（358.36 ±20.58）

P=0.000] and 14 d [（358.8±17.09）

P =0.000] respectively after intracerebral hemorrhage.The serum level of the MMP2[（454.23±43.34）

P=0.000] and the MMP9[（589.24±56.65）

P=0.000] reached the peak on 3 d after intracerebral hemorrhage.（2）The cerebral edema volume reached the peak on 7 d[（38.85±4.19）

P=0.000] after intracerebral hemorrhage

but the brain hematoma volume gradually decreased after illness.（3）The serum level of TSP2 was in weak negative correlation with the serum level of MMP9 after intracerebral hemorrhage（r=-0.14

P=0.000）;the serum level of TSP2 was negatively related to the brain hematoma（r=-0.57

P=0.000）;the serum level of MMP9 was positively related to the brain hematoma（r=0.73

P=0.000）;the serum level of MMP2（r=0.79

P=0.000）and MMP9（r=0.73

P=0.000）were positively related to the cerebral edema.Conclusion:The TSP may affects cerebral hematoma volume and edema surrounding bleeding through regulating MMP expression level after cerebral hemorrhage.