Objective:To investigate the efficacy and safety of different doses of domestic pregabalin on post-herpetic neuralgia（PHN）.Methods:A total of 45 PHN patients who met the inclusion criteria were divided into three groups randomly

and different doses of domestic pregabalin were given for 4 weeks

respectively.The efficacy was evaluated by visual analogue scale（VAS）

hospital anxiety and depression scale（HAD）

Medical Outcomes Study（MOS）sleep scale and adverse reactions before treatment and 1 week

2 weeks

3 weeks and 4 weeks after treatment respectively.Results:After 1 week

2 weeks

3 weeks and 4 weeks of treatment respectively

the VAS scores and MOS sleep scores of three groups decreased significantly compared with that before treatment

and the differences were statistically significant（P<0.05）.After 4 weeks

the HAD scores of three groups decreased significantly compared with that before treatment

and the differences were statistically significant（P<0.05）.However

the differences in VAS scores

rates of pain relief

MOS sleep scores and HAD scores were not statistically significant in the same period（P>0.05）.Finally

there were some transient and less severe adverse reactions among three groups

such as dizziness

dry mouth and somnolence

and the differences were statistically significant（P <0.05）.Other adverse reactions were not statistically significant（P >0.05）.Conclusion:For PHN patients

different doses of domestic pregabalin can alleviate the pain

and improve their anxiety

depression and sleep.The efficacy of domestic pregabalin is not necessarily dose-dependent

and its adverse reactions are mild

moderate and can be relieved by itself.